Polyuridylation

Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.^[1]

References

↑ Wilusz CJ, Wilusz J (2008). "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes Dev. 22 (1): 1–7. doi:10.1101/gad.1634508. PMC 2731568. PMID 18172159.

Post-transcriptional modification

Nuclear

Precursor mRNA
5′ cap formation
Polyadenylation
- CPSF
- CstF
- PAP
- PAB2
- CFI
- CFII
Poly(A)-binding protein
RNA editing
Polyuridylation

RNA splicing

Intron / Exon snRNP Spliceosome minor U1 Alternative splicing

pre-mRNA factors	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

Cytosolic

5′ cap methylation
mRNA decapping
- DCP1A
- DCP1B
- DCP2
- DCPS
- EDC3
- EDC4

This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.