RBM15

RBM15

Identifiers

RBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15

External IDs

MGI: 2443205 HomoloGene: 23383 GeneCards: RBM15

Gene ontology
Molecular function	• nucleotide binding • poly(A) RNA binding • protein binding • RNA binding • nucleic acid binding
Cellular component	• nuclear speck • nuclear membrane • membrane • nucleus • nucleoplasm
Biological process	• branching involved in blood vessel morphogenesis • ventricular septum morphogenesis • mRNA splicing, via spliceosome • placenta blood vessel development • viral process • negative regulation of myeloid cell differentiation • spleen development • negative regulation of transcription, DNA-templated • positive regulation of transcription of Notch receptor target
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


64783


229700


ENSG00000162775


ENSMUSG00000048109


Q96T37


n/a

RefSeq (mRNA)


NM_001201545 NM_022768


NM_001045807

RefSeq (protein)


NP_001188474.1 NP_073605.4


n/a

Location (UCSC)

Chr 1: 110.34 – 110.35 Mb

Chr 3: 107.33 – 107.33 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691.
↑ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
↑ "Entrez Gene: RBM15 RNA binding motif protein 15".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID 15849773.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Lindtner S, Zolotukhin AS, Uranishi H, et al. (2007). "RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.". J. Biol. Chem. 281 (48): 36915–28. doi:10.1074/jbc.M608745200. PMID 17001072.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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