RILP (gene)

RILP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YHN

Identifiers

Aliases

RILP, PP10141, Rab interacting lysosomal protein

External IDs

MGI: 2144271 HomoloGene: 19596 GeneCards: RILP

Gene ontology
Molecular function	• Rab GTPase binding • dynein light intermediate chain binding • protein binding
Cellular component	• endosome • late endosome • phagocytic vesicle membrane • membrane • late endosome membrane • protein complex • lysosomal membrane • mitochondrion • lysosome • cytoplasmic vesicle • endomembrane system • cytosol
Biological process	• positive regulation of protein catabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • endosome transport via multivesicular body sorting pathway • negative regulation of protein catabolic process • endosome to lysosome transport • early endosome to late endosome transport • intralumenal vesicle formation • regulation of multivesicular body size • transport • protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


83547


280408

Ensembl


n/a


ENSMUSG00000038195

UniProt


Q96NA2


Q5ND29

RefSeq (mRNA)


NM_031430


NM_001029938

RefSeq (protein)


NP_113618.2


NP_001025109.1

Location (UCSC)

Chr 17: 1.65 – 1.65 Mb

Chr 11: 75.51 – 75.51 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene.^[3]^[4]

Function

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]^[4]

Interactions

RILP (gene) has been shown to interact with RAB7A.^[3]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J. 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213.
1 2 "Entrez Gene: RILP Rab interacting lysosomal protein".
↑ Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.

Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors". Curr. Biol. 11 (21): 1680–5. doi:10.1016/S0960-9822(01)00531-0. PMID 11696325.
Wang T, Hong W (2003). "Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein". Mol. Biol. Cell. 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955.
Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S (2003). "Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP". Mol. Cell. Biol. 23 (18): 6494–506. doi:10.1128/MCB.23.18.6494-6506.2003. PMC 193691. PMID 12944476.
Wang T, Wong KK, Hong W (2004). "A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34". Mol. Biol. Cell. 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Wu M, Wang T, Loh E, Hong W, Song H (2005). "Structural basis for recruitment of RILP by small GTPase Rab7". EMBO J. 24 (8): 1491–501. doi:10.1038/sj.emboj.7600643. PMC 1142575. PMID 15933719.
Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF". J. Neurochem. 96 (4): 1130–8. doi:10.1111/j.1471-4159.2005.03608.x. PMID 16417580.
Marsman M, Jordens I, Rocha N, Kuijl C, Janssen L, Neefjes J (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment". Biochem. Biophys. Res. Commun. 344 (3): 747–56. doi:10.1016/j.bbrc.2006.03.178. PMID 16631113.
Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex". Biochem. Biophys. Res. Commun. 347 (4): 1074–9. doi:10.1016/j.bbrc.2006.07.007. PMID 16857164.

PDB gallery

1yhn: Structure basis of RILP recruitment by Rab7

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RILP (gene)

Function

Interactions

References

Further reading