SCFD1

Identifiers

SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2, sec1 family domain containing 1

External IDs

MGI: 1924233 HomoloGene: 5650 GeneCards: SCFD1

Gene ontology
Molecular function	• protein N-terminus binding • protein binding • syntaxin binding
Cellular component	• cytoplasm • cytosol • Golgi apparatus • endoplasmic reticulum membrane • membrane • cis-Golgi network • plasma membrane • Golgi transport complex • Golgi-associated vesicle • Golgi cisterna membrane • SNARE complex • endoplasmic reticulum
Biological process	• negative regulation of autophagosome assembly • regulation of ER to Golgi vesicle-mediated transport • response to hypoxia • regulation of protein transport • retrograde vesicle-mediated transport, Golgi to ER • toxin transport • post-Golgi vesicle-mediated transport • vesicle docking involved in exocytosis • COPII vesicle coating • cell morphogenesis • transport • phagocytosis • protein transport • response to toxic substance • vesicle-mediated transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


23256


76983

Ensembl


ENSG00000092108


ENSMUSG00000020952

UniProt


Q8WVM8


Q8BRF7

RefSeq (mRNA)

NM_001257376 NM_001283031 NM_001283032 NM_001283033 NM_016106
NM_182835


NM_029825 NM_001306178

RefSeq (protein)


NP_001244305.1 NP_001269961.1 NP_057190.2 NP_878255.1


NP_001293107.1 NP_084101.1

Location (UCSC)

Chr 14: 30.62 – 30.74 Mb

Chr 12: 51.38 – 51.45 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.^[3]

Interactions

SCFD1 has been shown to interact with USO1.^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: SCFD1 sec1 family domain containing 1".
↑ Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
↑ Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Mol. Biol. Cell. 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 32–7. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Matsuo N, Ogawa S, Takagi T, Wanaka A, Mori T, Matsuyama T, Pinsky DJ, Stern DM, Tohyama M (1997). "Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain". J. Biol. Chem. 272 (26): 16438–44. doi:10.1074/jbc.272.26.16438. PMID 9195952.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

PDB gallery

1y9j: Solution structure of the rat Sly1 N-terminal domain

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SCFD1

Interactions

References

Further reading