SCH-51866

SCH-51866
Names

IUPAC name (6aR,9aS)-5-Methyl-2-[4-(trifluoromethyl)benzyl]-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(3H)-one
Identifiers
3D model (Jmol)	Interactive image
ChemSpider	26377910
IUPHAR/BPS	5270
PubChem	15473392
InChI InChI=1S/C19H18F3N5O/c1-26-17(28)15-16(27-13-4-2-3-12(13)23-18(26)27)25-14(24-15)9-10-5-7-11(8-6-10)19(20,21)22/h5-8,12-13H,2-4,9H2,1H3,(H,24,25)/t12-,13+/m1/s1 Key: JOSMPBVYYKRYLG-OLZOCXBDSA-N
SMILES CN1C(=O)C2=C(N=C(N2)CC3=CC=C(C=C3)C(F)(F)F)N4C1=N[C@H]5[C@@H]4CCC5
Properties
Chemical formula	C₁₉H₁₈F₃N₅O
Molar mass	389.38 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

SCH-51866 is a phosphodiesterase inhibitor.^[1]^[2]

References

↑ "cGMP-phosphodiesterase antagonists inhibit Ca2+-influx in Dictyostelium discoideum and bovine cyclic-nucleotide-gated-channel". Eur. J. Pharmacol. 513 (1-2): 9–20. April 2005. doi:10.1016/j.ejphar.2005.01.047. PMID 15878705.
↑ Beaumont V, Park L, Rassoulpour A, et al. (2014). "The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease". PLoS Curr. 6. doi:10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca. PMC 3923778. PMID 24558637.

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