SCN4B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4MZ2, 4MZ3

Identifiers

Aliases

SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4

External IDs

OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B

Gene ontology
Molecular function	• sodium channel regulator activity • ion channel binding • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity
Cellular component	• voltage-gated sodium channel complex • integral component of membrane • membrane • intercalated disc • intrinsic component of plasma membrane • plasma membrane
Biological process	• cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • regulation of sodium ion transmembrane transporter activity • positive regulation of sodium ion transport • transport • AV node cell action potential • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • regulation of ventricular cardiac muscle cell membrane repolarization • regulation of postsynaptic membrane potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6330


399548

Ensembl


ENSG00000177098


ENSMUSG00000046480

UniProt


Q8IWT1


Q7M729

RefSeq (mRNA)


NM_001142348 NM_001142349 NM_174934


NM_001013390

RefSeq (protein)


NP_001135820.1 NP_001135821.1 NP_777594.1


NP_001013408.1

Location (UCSC)

Chr 11: 118.13 – 118.15 Mb

Chr 9: 45.14 – 45.15 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Sodium channel, also known as SCN4B is a protein which in humans is encoded by the SCN4B gene.^[3]

SCN4B is a sodium channel associated with long QT syndrome.^[4]

SCN4B functions as a cell adhesion molecule. ^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: sodium channel".
↑ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
↑ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.

Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.". J. Neurosci. 23 (20): 7577–85. PMID 12930796.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit.". Pflugers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMID 18941776.
Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.

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SCN4B

See also

References