SEC23IP

SEC23IP
Identifiers
Aliases	SEC23IP, P125, P125A, MSTP053, SEC23 interacting protein
External IDs	MGI: 2450915 HomoloGene: 38288 GeneCards: SEC23IP
Gene ontology Molecular function • poly(A) RNA binding • protein binding • metal ion binding • phospholipase activity Cellular component • cytoplasm • ER to Golgi transport vesicle membrane • cytosol • endoplasmic reticulum • membrane • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment • Golgi membrane • ER to Golgi transport vesicle Biological process • COPII vesicle coating • intracellular protein transport • Golgi organization • ER to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11196	207352
Ensembl	ENSG00000107651	ENSMUSG00000055319
UniProt	Q9Y6Y8	Q6NZC7
RefSeq (mRNA)	NM_007190	NM_001029982
RefSeq (protein)	NP_009121.1	n/a
Location (UCSC)	Chr 10: 119.89 – 119.94 Mb	Chr 7: 128.74 – 128.78 Mb
PubMed search	[1]	[2]
Wikidata

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.^[3][4]

COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.^[4]

References

Further reading