SH3

SH3 or SH-3 may refer to:

• SH3 domain, a protein structural domain thought to be involved in the formation of productive protein-protein binding interactions
• Renesas SH-3, a member of the SuperH microprocessor family, used in mobile and hand-held devices
• Silent Hill 3, the third installment in the Silent Hill survival horror video game series published by Konami
• Shadow Hearts: From The New World, the third game in the Shadow Hearts series.
• Silent Hunter III, a submarine simulation developed and published by Ubisoft.
• State Highway 3, a common highway name in many countries
• Sikorsky SH-3 Sea King, also known as "Sikorsky S-61", a military helicopter produced by the United States
• Stronghold 3 a medieval castle-building simulation game from Firefly Studios. released on September 30, 2011.
• The sulfur analogue of hydronium (H₃S⁺)