SNX15

Identifiers

SNX15, HSAF001435, sorting nexin 15

External IDs

MGI: 1916274 HomoloGene: 12294 GeneCards: SNX15

Gene ontology
Molecular function	• protein serine/threonine kinase activity • protein binding • phosphatidylinositol binding • lipid binding
Cellular component	• cytoplasm • cytosol • nucleolus • cytoplasmic vesicle membrane • membrane • intracellular membrane-bounded organelle • cytoplasmic vesicle
Biological process	• protein transport • intracellular protein transport • signal transduction • transport • protein phosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


29907


69024

Ensembl


ENSG00000110025


ENSMUSG00000024787

UniProt


Q9NRS6


Q91WE1

RefSeq (mRNA)


NM_147777 NM_013306


NM_026912

RefSeq (protein)


NP_037438.2 NP_680086.2


NP_081188.1

Location (UCSC)

Chr 11: 65.03 – 65.04 Mb

Chr 19: 6.12 – 6.13 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.^[3]^[4]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079.
1 2 "Entrez Gene: SNX15 sorting nexin 15".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Phillips SA, Barr VA, Haft DH, et al. (2001). "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking". J. Biol. Chem. 276 (7): 5074–84. doi:10.1074/jbc.M004671200. PMID 11085978.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Sorting nexins

SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33

SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29

SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31

Related articles	PX domain BAR domain Retromer

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SNX15

References

Further reading