SPRR1B

Identifiers

SPRR1B, CORNIFIN, GADD33, SPRR1, SPR-IB, small proline rich protein 1B

External IDs

Gene ontology
Molecular function	• protein binding, bridging • structural molecule activity
Cellular component	• cytoplasm • extracellular exosome • cornified envelope
Biological process	• keratinization • keratinocyte differentiation • epidermis development • peptide cross-linking
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6699


n/a

Ensembl


ENSG00000169469


n/a

UniProt


P22528


n/a

RefSeq (mRNA)


NM_003125


n/a

RefSeq (protein)


NP_003116.2


n/a

Location (UCSC)

Chr 1: 153.03 – 153.03 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Cornifin-B is a protein that in humans is encoded by the SPRR1B gene.^[2]^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
↑ Marvin KW, George MD, Fujimoto W, Saunders NA, Bernacki SH, Jetten AM (Dec 1992). "Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids". Proc Natl Acad Sci U S A. 89 (22): 11026–30. doi:10.1073/pnas.89.22.11026. PMC 50476. PMID 1438308.
↑ "Entrez Gene: SPRR1B small proline-rich protein 1B (cornifin)".

Fornace AJ (1993). "Mammalian genes induced by radiation; activation of genes associated with growth control.". Annu. Rev. Genet. 26: 507–26. doi:10.1146/annurev.ge.26.120192.002451. PMID 1482123.
An G, Huang TH, Tesfaigzi J, et al. (1992). "An unusual expression of a squamous cell marker, small proline-rich protein gene, in tracheobronchial epithelium: differential regulation and gene mapping.". Am. J. Respir. Cell Mol. Biol. 7 (1): 104–11. doi:10.1165/ajrcmb/7.1.104. PMID 1627333.
Kartasova T, van de Putte P (1988). "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.". Mol. Cell. Biol. 8 (5): 2195–203. PMC 363401. PMID 3133554.
Greco MA, Lorand L, Lane WS, et al. (1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.". J. Invest. Dermatol. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
An G, Tesfaigzi J, Chuu YJ, Wu R (1993). "Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP.". J. Biol. Chem. 268 (15): 10977–82. PMID 8388378.
Austin SJ, Fujimoto W, Marvin KW, et al. (1996). "Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids.". J. Biol. Chem. 271 (7): 3737–42. doi:10.1074/jbc.271.7.3737. PMID 8631988.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Robinson NA, Lapic S, Welter JF, Eckert RL (1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.". J. Biol. Chem. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
Lee CH, Marekov LN, Kim S, et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.". FEBS Lett. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
Reddy SP, Adiseshaiah P, Shapiro P, Vuong H (2002). "BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells.". Am. J. Respir. Cell Mol. Biol. 27 (1): 64–70. doi:10.1165/ajrcmb.27.1.20020003oc. PMID 12091247.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tesfaigzi Y, Wright PS, Belinsky SA (2003). "SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4): L889–98. doi:10.1152/ajplung.00065.2003. PMID 12832281.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

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SPRR1B

References

Further reading