Sequestosome 1

SQSTM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9
Identifiers
Aliases	SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1
External IDs	MGI: 107931 HomoloGene: 31202 GeneCards: SQSTM1
Genetically Related Diseases
Alzheimer's disease[1]
Gene ontology Molecular function • protein homodimerization activity • receptor tyrosine kinase binding • zinc ion binding • SH2 domain binding • metal ion binding • protein serine/threonine kinase activity • K63-linked polyubiquitin binding • protein binding • identical protein binding • protein kinase binding • ubiquitin protein ligase binding • protein kinase C binding • ubiquitin binding Cellular component • cytoplasm • cytosol • endosome • PML body • late endosome • cytoplasmic mRNA processing body • pre-autophagosomal structure • nucleoplasm • aggresome • autophagosome • amphisome • endoplasmic reticulum • inclusion body • lysosome • sperm midpiece • extracellular exosome • cytoplasmic vesicle • nucleus • autolysosome Biological process • apoptotic process • protein localization • cell differentiation • positive regulation of protein phosphorylation • intracellular signal transduction • mitophagy in response to mitochondrial depolarization • ubiquitin-dependent protein catabolic process • negative regulation of growth of symbiont in host • regulation of mitochondrion organization • protein heterooligomerization • immune system process • response to stress • regulation of Ras protein signal transduction • negative regulation of apoptotic process • autophagy • endosomal transport • regulation of protein complex stability • positive regulation of macroautophagy • mitophagy • positive regulation of apoptotic process • macroautophagy • regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • protein phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8878	18412
Ensembl	ENSG00000161011	ENSMUSG00000015837
UniProt	Q13501	Q64337
RefSeq (mRNA)	NM_001142298 NM_001142299 NM_003900	NM_001290769 NM_011018
RefSeq (protein)	NP_001135770.1 NP_001135771.1 NP_003891.1	NP_001277698.1 NP_035148.1
Location (UCSC)	Chr 5: 179.81 – 179.84 Mb	Chr 11: 50.2 – 50.21 Mb
PubMed search	[2]	[3]
Wikidata

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene.^[4][5][6] Also known as the ubiquitin-binding protein p62,^[7] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.^[8]

Model organisms

Model organisms have been used in the study of SQSTM1 function. A conditional knockout mouse line, called Sqstm1^{tm1a(KOMP)Wtsi[14][15]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[12][19] Twenty two tests were carried out on homozygous mutant mice and one significant abnormality was observed: females had abnormal complete blood count parameters, including an increased red blood cell distribution width and increased mean platelet volume.^[12]

Interactions

Sequestosome 1 has been shown to interact with:

References

Further reading

PDB gallery
1q02: NMR structure of the UBA domain of p62 (SQSTM1)