Samir Mitragotri

Samir Mitragotri
Born (1971-05-28) May 28, 1971
Solapur, India
Residence United States
Fields Chemical Engineering, Biomedical Engineering
Institutions University of California, Santa Barbara
Duncan and Suzanne Mellichamp Chair in Systems Biology and Bioengineering
Professor, Chemical Engineering
Director, Center of BioEngineering
Affiliated Faculty, Technology Management Program
Alma mater B.S., Institute of Chemical Technology, 1992
M.S. and Ph.D., Massachusetts Institute of Technology, 1996
Doctoral advisor Robert S. Langer, Daniel Blankschtein
Known for Drug Delivery, Biomaterials
Notable awards National Academy of Engineering
National Academy of Medicine

Samir Mitragotri (born May 28, 1971) is an Indian American Professor at the University of California, Santa Barbara, an inventor, an entrepreneur, and a researcher in the fields of drug delivery and biomaterials.[1] He is the Duncan and Suzanne Mellichamp Chair in Systems Biology and Bioengineering and the Founding Director of the UC Santa Barbara Center for BioEngineering.[2][3]

Prof. Mitragotri has made groundbreaking contributions to the field of drug delivery by advancing fundamental understanding of biological barriers and developing new materials and technologies for drug delivery. Many of his technologies have advanced to human clinical studies and products.

Prof. Mitragotri has established a fundamental knowledge platform of transport properties of skin. He also developed mathematical models of skin permeation and analytical tools to study biophysics of skin structure-function relationship.[4] He has pioneered a large number of technologies including low-frequency ultrasound,[5] pulsed microjet injector,[6] high throughput skin experimentation,[7] skin penetrating peptides[8] and ionic liquids[9] for transdermal delivery of proteins, peptides and nucleic acids.

Prof. Mitragotri has also developed fundamental understanding of trans-epithelial transport in the intestine. He also developed novel technologies, in particular intestinal patches, for oral delivery of proteins such as insulin and calcitonin.[10]

Prof. Mitragotri has designed and synthesized unique bio-inspired nanoparticles of novel physical, chemical and biological properties to understand the fundamental principles of body’s immune barrier.[11] He developed novel particles that mimic red blood cells[12] and platelets[13] as well as hybrid systems that make use of synthetic nanoparticles hitchhiking on natural cells for targeted delivery of drugs.[14]

Mitragotri has published over 210 publications in the area of drug delivery and biomaterials, has given close to 500 invited and contributed presentations worldwide, and is an inventor on over 110 patents/applications. His publications are cited with an h-index of 78.[15] Mitragotri is a co-founder of several companies that are developing products based on his inventions for detection and treatment of various human diseases. He received his Ph.D. in Chemical Engineering at MIT and B.S. in Chemical Engineering from the Institute of Chemical Technology. Mitragotri serves on the editorial boards of several journals and currently serves as Editor-in-Chief of Bioengineering and Translational Medicine.

Awards and Honors

Mitragotri's national and international awards include:

Journal Associations

Biotech Companies

Samir Mitragotri has co-founded several companies:

References

  1. ↑ "Mitragotri Laboratory, UCSB Chemical Engineering". Drug Delivery UCSB Engineering. The Regents of the University of California. Retrieved 14 October 2014.
  2. ↑ "Endowed Chairs". UCSB Institutional Advancement, Office of Development. The Regents of the University of California. Retrieved 14 October 2014.
  3. ↑ "People". UCSB Center for BioEngineering. The Regents of the University of California. Retrieved 14 October 2014.
  4. ↑ Karande, P.; Jain, A.; Ergun, K.; Kispersky, V.; Mitragotri, S. (17 March 2005). "Design principles of chemical penetration enhancers for transdermal drug delivery". Proceedings of the National Academy of Sciences. 102 (13): 4688–4693. doi:10.1073/pnas.0501176102.
  5. ↑ Mitragotri, S.; Blankschtein, D.; Langer, R. (11 August 1995). "Ultrasound-mediated transdermal protein delivery". Science. 269 (5225): 850–853. doi:10.1126/science.7638603.
  6. ↑ Arora, A.; Hakim, I.; Baxter, J.; Rathnasingham, R.; Srinivasan, R.; Fletcher, D. A.; Mitragotri, S. (6 March 2007). "Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets". Proceedings of the National Academy of Sciences. 104 (11): 4255–4260. doi:10.1073/pnas.0700182104.
  7. ↑ Karande, Pankaj; Jain, Amit; Mitragotri, Samir (4 January 2004). "Discovery of transdermal penetration enhancers by high-throughput screening". Nature Biotechnology. 22 (2): 192–197. doi:10.1038/nbt928.
  8. ↑ Hsu, T.; Mitragotri, S. (8 September 2011). "Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer". Proceedings of the National Academy of Sciences. 108 (38): 15816–15821. doi:10.1073/pnas.1016152108.
  9. ↑ Zakrewsky, Michael; Lovejoy, Katherine S.; Kern, Theresa L.; Miller, Tarryn E.; Le, Vivian; Nagy, Amber; Goumas, Andrew M.; Iyer, Rashi S.; Del Sesto, Rico E.; Koppisch, Andrew T.; Fox, David T.; Mitragotri, Samir (16 September 2014). "Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization". Proceedings of the National Academy of Sciences. 111 (37): 13313–13318. doi:10.1073/pnas.1403995111.
  10. ↑ Gupta, Vivek; Hwang, Byeong Hee; Lee, JooHee; Anselmo, Aaron C.; Doshi, Nishit; Mitragotri, Samir (December 2013). "Mucoadhesive intestinal devices for oral delivery of salmon calcitonin". Journal of Controlled Release. 172 (3): 753–762. doi:10.1016/j.jconrel.2013.09.004.
  11. ↑ Champion, J. A.; Mitragotri, S. (20 March 2006). "Role of target geometry in phagocytosis". Proceedings of the National Academy of Sciences. 103 (13): 4930–4934. doi:10.1073/pnas.0600997103.
  12. ↑ Doshi, N.; Zahr, A. S.; Bhaskar, S.; Lahann, J.; Mitragotri, S. (14 December 2009). "Red blood cell-mimicking synthetic biomaterial particles". Proceedings of the National Academy of Sciences. 106 (51): 21495–21499. doi:10.1073/pnas.0907127106.
  13. ↑ Anselmo, Aaron C.; Modery-Pawlowski, Christa Lynn; Menegatti, Stefano; Kumar, Sunny; Vogus, Douglas R.; Tian, Lewis L.; Chen, Ming; Squires, Todd M.; Sen Gupta, Anirban; Mitragotri, Samir (25 November 2014). "Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries". ACS Nano. 8 (11): 11243–11253. doi:10.1021/nn503732m.
  14. ↑ Anselmo, Aaron C.; Gupta, Vivek; Zern, Blaine J.; Pan, Daniel; Zakrewsky, Michael; Muzykantov, Vladimir; Mitragotri, Samir (23 December 2013). "Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells". ACS Nano. 7 (12): 11129–11137. doi:10.1021/nn404853z.
  15. ↑ "Samir Mitragotri". Google Scholar. Google Scholar. Retrieved 14 October 2014.
  16. ↑ "National Academy of Medicine Elects 79 New Members". National Academy of Medicine. National Academy of Sciences. Retrieved 26 October 2016.
  17. ↑ "BMES members elected to 2015 National Academy of Engineers class". BMES. Biomedical Engineering Society. Retrieved 4 January 2016.
  18. ↑ Baumer, Katie. "AAPS Announces 2015 Fellows". AAPS. American Association of Pharmaceutical Scientists (AAPS). Retrieved 4 January 2016.
  19. ↑ "College of Fellows". Controlled Release Society. Controlled Release Society. Retrieved 1 July 2015.
  20. ↑ "Professional Progress in Chemical Engineering". AIChE: The Global Home of Chemical Engineers. American Institute of Chemical Engineers. Retrieved 1 July 2015.
  21. ↑ Atkins, Randy. "National Academy of Engineering Elects 67 Members and 12 Foreign Members". National Academy of Engineering. Retrieved 7 February 2015.
  22. ↑ "Current NAI Fellows". National Academy of Inventors. The National Academy of Inventors. Retrieved 14 October 2014.
  23. ↑ Fernandez, Sonia. "Two UCSB Engineering Professors Named to National Academy of Inventors". The UC Santa Barbara Current: Science & Technology. The Regents of the University of California. Retrieved 17 December 2013.
  24. ↑ "AAAS Members Elected as Fellows". AAAS. American Association for the Advancement of Science. Retrieved 30 November 2012.
  25. ↑ "Eight Distinguished UCSB Faculty Members Named AAAS Fellows". UCSB Institutional Advancement: Public Affairs & Communications. The Regents of the University of California. Retrieved 29 November 2012.
  26. ↑ "Fellow Directory". AIMBE. American Institute for Medical and Biological Engineering. Retrieved 30 September 2014.
  27. ↑ "CRS Young Investigator Award Recipients". CRS: Controlled Release Society. Controlled Release Society. Retrieved 14 October 2014.
  28. ↑ "Allan P. Colburn Award for Excellence in Publications by a Young Member of the Institute". AIChE: The Global Home of Chemical Engineers. American Institute of Chemical Engineers. Retrieved 14 October 2014.
  29. ↑ "Samir Mitragotri, 28". MIT Technology Review. MIT Technology Review. Retrieved 2013. Check date values in: |access-date= (help)
  30. ↑ "Bioengineering & Translational Medicine". AIChE. American Institute of Chemical Engineers. Retrieved 4 January 2016.
  31. ↑ "Editorial Board, Journal of Controlled Release". Elsevier. Elsevier B.V. Retrieved 14 October 2014.
  32. ↑ "European Journal of Pharmaceutical Sciences Editorial Board". Elsevier. Elsevier B.V. Retrieved 14 October 2014.
  33. ↑ Echo Therapeutics: Needle-free monitoring and drug delivery. Echo Therapeutics http://www.echotx.com/. Retrieved 14 October 2014. Missing or empty |title= (help)
  34. ↑ "Scientific Advisors". Seventh Sense Biosystems. Seventh Sense Biosystems, Inc. Retrieved 14 October 2014.
  35. ↑ "Team". entrega. Entrega Bio. Retrieved 14 October 2014.
  36. ↑ "CTX Acquires Promising Proprietary Drug Delivery Assets". Business Wire. Business Wire. Retrieved 4 January 2016.
This article is issued from Wikipedia - version of the 12/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.