Shigeo Ohno

Shigeo Ohno (大野 茂男 Ōno Shigeo, born March 1952) is a Japanese molecular biologist and professor at Yokohama City University School of Medicine, known for his pioneer research on Protein Kinase C and cell polarity.

Biography

Ohno was born in 1952 in Niigata prefecture, Japan, and received his B.S. in 1975 and his Ph.D. in 1980 from the University of Tokyo.[1] He served as a postdoctoral fellow at the Cancer Institute, Japanese Foundation for Cancer Research to investigate the cDNA of Interferon gene with Tadatsugu Taniguchi.[2][3] He was a research associate at Tokyo Metropolitan Institute of Medical Science to study molecular cloning of Calpain[4] and Protein Kinase C.[5] He became a professor of Biochemistry at Yokohama City University School of Medicine in 1991.

Contribution

In 1998, he and his colleagues found the atypical PKC-specific interacting protein (ASIP) which is mammalian homologue of Caenorhabditis elegans Par3.[6] This led to the finding of a conserved Par3-Par6-atypical PKC complex responsible for regulating cell polarity.

Honors and awards

Editorial activities

Ohno previously served as an editor of The Journal of Biochemistry.

References

  1. ↑ Shigeo Ohno, CDB Symposium 2009 Speaker
  2. ↑ Taniguchi, T.; Ohno, S.; Fujii-Kuriyama, Y.; Muramatsu, M. (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–15. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
  3. ↑ Ohno, S; Taniguchi, T (1981). "Structure of a chromosomal gene for human interferon beta". Proceedings of the National Academy of Sciences of the United States of America. 78 (9): 5305–9. doi:10.1073/pnas.78.9.5305. PMC 348733Freely accessible. PMID 16593086.
  4. ↑ Ohno, S; Emori, Y; Imajoh, S; Kawasaki, H; Kisaragi, M; Suzuki, K (1984). "Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?". Nature. 312 (5994): 566–70. doi:10.1038/312566a0. PMID 6095110.
  5. ↑ Ohno, S; Kawasaki, H; Imajoh, S; Suzuki, K; Inagaki, M; Yokokura, H; Sakoh, T; Hidaka, H (1987). "Tissue-specific expression of three distinct types of rabbit protein kinase C". Nature. 325 (7000): 161–6. doi:10.1038/325161a0. PMID 3808073.
  6. ↑ Izumi, Y; Hirose, T; Tamai, Y; Hirai, S; Nagashima, Y; Fujimoto, T; Tabuse, Y; Kemphues, K. J.; Ohno, S (1998). "An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3". The Journal of Cell Biology. 143 (1): 95–106. doi:10.1083/jcb.143.1.95. PMC 2132825Freely accessible. PMID 9763423.

External links


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