Small Cajal body specific RNA 14

Small Cajal body specific RNA 14

Predicted secondary structure and sequence conservation of SCARNA14
Identifiers
Symbol SCARNA14
Alt. Symbols snoU100
Rfam RF00582
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO 0006396 0015030 0005730
SO 0000275

In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies.

scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs.[3]

U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family.[4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7.[5]

References

  1. ↑ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017Freely accessible. PMID 12032087.
  2. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552Freely accessible. doi:10.1093/nar/gkj002. PMC 1347365Freely accessible. PMID 16381836.
  3. ↑ Vitali, Patrice; Royo, Hélène; Seitz, Hervé; Bachellerie, Jean‐Pierre; Hüttenhofer, Alexander; Cavaillé, Jérôme (15 November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research. 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545Freely accessible. PMID 14602913.
  4. ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495Freely accessible. PMID 11387227.
  5. ↑ Schattner, P.; Barberan-Soler, S.; Lowe, T. M. (January 2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881Freely accessible. PMID 16373490.
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