TRAK1

TRAK1

Identifiers

TRAK1, MILT1, OIP106, trafficking kinesin protein 1

External IDs

MGI: 1914345 HomoloGene: 25103 GeneCards: TRAK1

Gene ontology
Molecular function	• protein binding • GABA receptor binding
Cellular component	• cytoplasm • endosome • early endosome • mitochondrion • nucleus
Biological process	• regulation of transcription from RNA polymerase II promoter • protein targeting • protein O-linked glycosylation • endosome to lysosome transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


22906


67095


ENSG00000182606


ENSMUSG00000032536


Q9UPV9


Q6PD31

RefSeq (mRNA)


NM_001042646 NM_001265608 NM_001265609 NM_001265610 NM_014965


NM_175114

RefSeq (protein)


NP_001036111.1 NP_001252537.1 NP_001252539.1 NP_055780.2


NP_780323.2

Location (UCSC)

Chr 3: 42.01 – 42.23 Mb

Chr 9: 121.37 – 121.47 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.^[3]^[4]^[5]^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
↑ Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
↑ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
↑ "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.

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