TRPA1 receptor agonist
TRPA1 receptor agonists are substances that agonize transient receptor potential cation channel, member A1 receptors.[1][2]
Effects
Hypothesized molecular identity of cold-sensitive afferents based upon the expression of TRPM8 and TRPA1
TRPA1 agonists have been and remain the subject of research into their potential thermoreceptoric activity.[1][2]
Examples
- 4-oxo-2-nonenal
- Icilin
- Polygodial
- Hepoxilins A3 and B3
- 12S-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (see 12-Hydroxyeicosatetraenoic acid)
- 4,5-Epoxyeicosatrienoic acid (see Epoxyeicosatrienoic acid)
References
- 1 2 McKemy, David D. (2005-04-22). "How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation". Molecular Pain. 1 (16). doi:10.1186/1744-8069-1-16. Retrieved 2012-08-27.
- 1 2 Rawls, Scott M.; Teresa Gomez; Zhe Ding; Robert B. Raffa (2007-12-01). "Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5)". European Journal of Pharmacology. 575 (1–3): 103–104. doi:10.1016/j.ejphar.2007.07.060. PMID 17765220.
See also
- Calcitonin gene-related peptide
- TRPA1 receptor antagonist
- TRPM8 receptor agonist
- TRPV1
- Substance P
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