Tripamide

Tripamide
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code none
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
CAS Number 73803-48-2
PubChem (CID) 636401
UNII G36A0E9CVT YesY
ChEMBL CHEMBL2104484
Chemical and physical data
Formula C16H20ClN3O3S
Molar mass 369.86
3D model (Jmol) Interactive image
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Tripamide (INN) is a diuretic.

Synthesis

Tripamide synthesis:[1]

Preparation starts by exhaustive reduction of the Diels-Alder adduct from cyclopentadiene and maleimide (1). Nitrosation of the product (2), followed by reduction of the nitroso group of 3, gives the corresponding hydrazine (4). Acylation with acid chloride 5 gives tripamide (6).

References


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