VAPA

VAPA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases VAPA, VAP-33, VAP-A, VAP33, hVAP-33, VAMP associated protein A
External IDs MGI: 1353561 HomoloGene: 37824 GeneCards: VAPA
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9218

30960

Ensembl

ENSG00000101558

ENSMUSG00000024091

UniProt

Q9P0L0

Q9WV55

RefSeq (mRNA)

NM_003574
NM_194434

NM_013933

RefSeq (protein)

NP_003565.4
NP_919415.2

NP_038961.2

Location (UCSC) Chr 18: 9.91 – 9.96 Mb Chr 17: 65.58 – 65.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicle-associated membrane protein-associated protein A is a protein that in humans is encoded by the VAPA gene.[3][4][5]

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[5]

Interactions

VAPA has been shown to interact with OSBP.[6] This interaction is mediated by the FFAT motif in OSBP.

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Nishimura Y, Hayashi M, Inada H, Tanaka T (Feb 1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem Biophys Res Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
  4. Weir ML, Klip A, Trimble WS (Sep 1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP". Biochem J. 333 (2): 247–51. doi:10.1042/bj3330247. PMC 1219579Freely accessible. PMID 9657962.
  5. 1 2 "Entrez Gene: VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa".
  6. Wyles, Jessica P; McMaster Christopher R; Ridgway Neale D (Aug 2002). "Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum". J. Biol. Chem. United States. 277 (33): 29908–18. doi:10.1074/jbc.M201191200. ISSN 0021-9258. PMID 12023275.

Further reading


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