Vinca alkaloid

Chemical structure of the vinca alkaloid vincristine

Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus (basionym Vinca rosea) and other vinca plants.

Vinca alkaloids are used in chemotherapy for cancer. They are a class of cell cycle–specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting upon tubulin, they prevent it from forming into microtubules, a necessary component for cellular division.[1]

Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These compounds include vinblastine, vincristine, vindesine, and vinorelbine.

Additional researched vinca alkaloids include vincaminol, vineridine, and vinburnine.

Vinpocetine is a semisynthetic derivative of the vinca alkaloid vincamine (sometimes described as "a synthetic ethyl ester of apovincamine").[2]

Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine.[3][4][5]

References

  1. ↑ Takimoto, C. H.; Calvo, E. (2008). "Chapter 3: Principles of Oncologic Pharmacotherapy". In Pazdur, R.; Wagman, L. D.; Camphausen, K. A.; Hoskins, W. J. Cancer Management: A Multidisciplinary Approach (11th ed.). ISBN 978-1-891483-62-2.
  2. ↑ Lörincz C, Szász K, Kisfaludy L (1976). "The synthesis of ethyl apovincaminate". Arzneimittel-Forschung. 26 (10a): 1907. PMID 1037211.
  3. ↑ Plat, M; Fellion, E; Le Men, J; Janot, M (1962). "4 new alkaloids of Vinca minor L.: minovincine, methoxyminovincine, minovincinine and (-) vincadifformine, alkaloids of periwinkles". Ann. Pharm. Fr. (in French). 20: 899–906. PMID 13943964.
  4. ↑ Smeyers, Yves G.; Smeyers, Nadine J.; Randez, Juan J.; Hernandez-Laguna, A.; Galvez-Ruano, E. (1991). "A structural and pharmacological study of alkaloids of Vinca Minor". Molecular Engineering. 1 (2): 153. doi:10.1007/BF00420051.
  5. ↑ Janot, M. M.; Le Men, J; Fan, C (1958). "The alkaloids of the periwinkles (Vinca): Relation between, vincamedine and vincamajine". Comptes rendus hebdomadaires des seances de l'Academie des sciences. 247 (25): 2375–7. PMID 13619121.

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