WDR57

SNRNP40
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SNRNP40, 40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57, small nuclear ribonucleoprotein U5 subunit 40
External IDs MGI: 1913835 HomoloGene: 3538 GeneCards: SNRNP40
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9410

66585

Ensembl

ENSG00000060688

n/a

UniProt

Q96DI7

Q6PE01

RefSeq (mRNA)

NM_004814

NM_025645

RefSeq (protein)

NP_004805.2

NP_079921.2

Location (UCSC) Chr 1: 31.26 – 31.3 Mb Chr 4: 130.36 – 130.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.[3]

Function

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.[3]

Interactions

WDR57 has been shown to interact with PRPF8[4][5] and EFTUD2.[4][5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific)".
  4. 1 2 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931.
  5. 1 2 Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R (Nov 1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259Freely accessible. PMID 9774689.

Further reading

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.