Transient tachypnea of the newborn

Transient tachypnea of the newborn
Classification and external resources
Specialty	pediatrics
ICD-10	P22.1
ICD-9-CM	770.6
DiseasesDB	32373
MedlinePlus	007233
eMedicine	ped/2597 radio/710

Transient tachypnea of the newborn (TTN, TTNB, or "transitory tachypnea of newborn") is a respiratory problem that can be seen in the newborn shortly after delivery. Amongst causes of respiratory distress in term neonates, it is the most common.^[1]^[2] It consists of a period of rapid breathing (higher than the normal range of 30-60 times per minute). It is likely due to retained lung fluid. It is most often seen in 35+ week gestation babies who are delivered by caesarian section without labor. Usually, this condition resolves over 24–48 hours. Treatment is supportive and may include supplemental oxygen and antibiotics. The chest x-ray shows hyperinflation of the lungs including prominent pulmonary vascular markings, flattening of the diaphragm, and fluid in the horizontal fissure of the right lung.

Pathophysiology

Due to the higher incidence of TTN in newborns delivered by caesarean section, it has been postulated that TTN could result from a delayed absorption of fetal lung fluid from the pulmonary lymphatic system. The increased fluid in the lungs leads to increased airway resistance and reduced lung compliance. It is thought this could be from lower levels of circulating catecholamines after a caesarean section, which are believed to be necessary to alter the function of the ENaC channel to absorb excess fluid from the lungs.
Pulmonary immaturity has also been proposed as a causative factor. Levels of phosphatidylglycerol (an indicator of lung maturity) were found to be negative in certain newborns.
Mild surfactant deficiency has also been suggested as a causative factor.

Clinical evaluation

TTN is a diagnosis of exclusion as it is a benign condition that can have symptoms and signs similar to more serious conditions, such as respiratory distress syndrome.^[1] A chest X-ray may show a radiopaque line - fluid - in the horizontal fissure of the right lung, fluid infiltrate throughout alveoli or fluid in individual lung lobes.^[1]

References

1 2 3 Lissauer T, Clayden,(2007). Illustrated textbook of paediatrics (3rd ed.). Mosby/Elsevier. p. 162. ISBN 0-7234-3397-6
↑ Hermansen CL, Lorah KN (October 2007). "Respiratory distress in the newborn". Am Fam Physician. 76 (7): 987–94. PMID 17956068.

Certain conditions originating in the perinatal period / fetal disease (P, 760–779)

Maternal factors and
complications of pregnancy,
labour and delivery

placenta:	Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome

chorion/amnion:	Chorioamnionitis

umbilical cord:	Umbilical cord prolapse Nuchal cord Single umbilical artery

Length of gestation
and fetal growth

Birth trauma

By system

Respiratory	Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome pleural disease Pneumothorax Pneumomediastinum Wilson–Mikity syndrome Bronchopulmonary dysplasia

Cardiovascular	Pneumopericardium Persistent fetal circulation

Haemorrhagic and hematologic disease	Vitamin K deficiency Haemorrhagic disease of the newborn HDN ABO Anti-Kell Rh c Rh D Rh E Hydrops fetalis Hyperbilirubinemia Kernicterus Neonatal jaundice Velamentous cord insertion Intraventricular hemorrhage Germinal matrix hemorrhage Anemia of prematurity

Digestive	Ileus Necrotizing enterocolitis Meconium peritonitis

Integument and thermoregulation	Erythema toxicum Sclerema neonatorum

Nervous system	Periventricular leukomalacia

Musculoskeletal	Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia

Infectious

Other

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