Oocyte selection

Oocyte selection is a procedure that is performed prior to in vitro fertilization, in order to use oocytes with maximal chances of resulting in pregnancy. In contrast, embryo selection takes place after fertilization.

Techniques

Chromosomal evaluation may be performed. Embryos from rescued in vitro-matured metaphase II (IVM-MII) oocytes show significantly higher fertilization rates and more blastomeres per embryo compared with those from arrested metaphase I (MI) oocytes (58.5% vs. 43.9% and 5.7 vs. 5.0, respectively).^[1]

Also, morphological features of the oocyte that can be obtained by standard light or polarized light microscopy. However, there is no clear tendency in recent publications to a general increase in predictive value of morphological features.^[2] Suggested techniques include zona pellucida imaging, which can detect differences in birefringence between eggs, which is a predictor of compaction, blastulation and pregnancy.^[3]

Potentially, polar body biopsy may be used for molecular analysis, and can be used for preimplantation genetic screening.^[4]

References

↑ Strassburger D, Goldstein A, Friedler S, et al. (June 2009). "The cytogenetic constitution of embryos derived from immature (metaphase I) oocytes obtained after ovarian hyperstimulation". Fertil. Steril. 94 (3): 971–978. doi:10.1016/j.fertnstert.2009.04.035. PMID 19505687.
↑ Rienzi, L.; Vajta, G.; Ubaldi, F. (2010). "Predictive value of oocyte morphology in human IVF: a systematic review of the literature". Human Reproduction Update. 17 (1): 34–45. doi:10.1093/humupd/dmq029. PMC 3001337. PMID 20639518.
↑ Ebner T, Balaban B, Moser M, et al. (May 2009). "Automatic user-independent zona pellucida imaging at the oocyte stage allows for the prediction of preimplantation development". Fertil. Steril. 94 (3): 913–920. doi:10.1016/j.fertnstert.2009.03.106. PMID 19439291.
↑ Jiao, Ze-Xu; Woodruff, Teresa K. (2013). "Detection and quantification of maternal-effect gene transcripts in mouse second polar bodies: potential markers of embryo developmental competence". Fertility and Sterility. 99 (7): 2055–2061. doi:10.1016/j.fertnstert.2013.02.003. ISSN 0015-0282.

Assisted reproductive technology

Infertility	Female Male Fertility clinic Fertility testing Fertility tourism

Fertility medication	Estrogen antagonists aromatase inhibitor clomifene FSH GnRH agonists Gonadotropins menotropins hCG

In vitro fertilisation (IVF) and expansions	Assisted zona hatching Autologous endometrial coculture Cytoplasmic transfer Embryo transfer Gestational carrier In vitro maturation Intracytoplasmic sperm injection Oocyte selection Ovarian hyperstimulation Preimplantation genetic diagnosis Snowflake children Transvaginal ovum retrieval Zygote intrafallopian transfer

Other methods	Artificial insemination sperm donation Cryopreservation embryos oocyte ovarian tissue semen Gamete intrafallopian transfer Reproductive surgery vasectomy reversal Semen collection Sex selection Surrogacy

Donation	Donor registration Donor Sibling Registry Egg donation Embryo Sperm Sperm bank

Ethics	Accidental incest Religious response to ART Mitochondrial donation

In fiction	See subsection in sperm donation Reproduction and pregnancy in speculative fiction

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