CDC25B

CDC25B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU, 4WH7, 4WH9
Identifiers
Aliases	CDC25B
External IDs	MGI: 99701 HomoloGene: 41451 GeneCards: CDC25B
Gene ontology Molecular function • protein binding • protein tyrosine phosphatase activity • hydrolase activity • protein kinase binding • phosphoprotein phosphatase activity Cellular component • cytoplasm • cytosol • centrosome • spindle pole • intracellular • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus Biological process • mitotic nuclear division • protein dephosphorylation • positive regulation of mitotic cell cycle • cell division • positive regulation of cytokinesis • protein phosphorylation • G2/M transition of mitotic cell cycle • oocyte maturation • positive regulation of cell proliferation • mitotic cell cycle • cell cycle • female meiosis I • positive regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	994	12531
Ensembl	ENSG00000101224	ENSMUSG00000027330
UniProt	P30305	P30306
RefSeq (mRNA)	NM_001287516 NM_001287517 NM_001287518 NM_001287519 NM_001287520 NM_001287522 NM_001287524 NM_004358 NM_021872 NM_021873 NM_021874 NM_212530	NM_001111075 NM_023117
RefSeq (protein)	NP_001274448.1 NP_001274453.1 NP_004349.1 NP_068658.1 NP_068659.1	NP_075606.1
Location (UCSC)	Chr 20: 3.79 – 3.81 Mb	Chr 2: 131.19 – 131.2 Mb
PubMed search	[1]	[2]
Wikidata

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.^[3]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.^[4]

Interactions

CDC25B has been shown to interact with MAPK14,^[5] Casein kinase 2, alpha 1,^[6] CHEK1,^[7] MELK,^[8] Estrogen receptor alpha,^[9] YWHAB,^[10][11] YWHAZ,^[10] YWHAH^[10] and YWHAE.^[10][11]

References

Further reading

PDB gallery
1cwr: HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE  1cws: HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE  1cwt: HUMAN CDC25B CATALYTIC DOMAIN WITH METHYL MERCURY  1qb0: HUMAN CDC25B CATALYTIC DOMAIN  1ym9: Crystal structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfinic form  1ymd: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfonic form  1ymk: Crystal Structure of the CDC25B phosphatase catalytic domain in the apo form  1yml: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the sulfenic form  1ys0: Crystal Structure of the CDC25B phosphatase catalytic domain with the active site cysteine in the disulfide form  2a2k: Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain  2ifd: Crystal structure of a remote binding site mutant, R492L, of CDC25B Phosphatase catalytic domain  2ifv: Crystal structure of an active site mutant, C473D, of CDC25B phosphatase catalytic domain