Denaverine

Denaverine
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • Gr 1 (Germany)
Routes of
administration
intramuscular injection, suppositories
ATCvet code QG02CX90 (WHO)
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 8% (suppositories),
37% (oral solution)
Metabolism mainly hepatic, at least 11 metabolites
Biological half-life 34 hours
Identifiers
CAS Number 3579-62-2 YesY
3321-06-0 (hydrochloride)
PubChem (CID) 71130
ChemSpider 64278 N
UNII O14NF38MTL YesY
KEGG D07787 YesY
ChEMBL CHEMBL1614656 N
Chemical and physical data
Formula C24H33NO3
Molar mass 383.52 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]

References

  1. Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
  2. Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
  3. Dinnendahl, V; Fricke, U, eds. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.


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