Douglas Kell

Douglas Kell

Douglas Kell at Buckingham Palace with Carole Goble after receiving his CBE
Born Douglas Bruce Kell
(1953-04-07) 7 April 1953[1]
Nationality United Kingdom
Fields
Institutions
Alma mater University of Oxford (BA, PhD)
Thesis The Bioenergetics of Paracoccus denitrificans (1978)
Doctoral advisor
  • Stuart Ferguson[3]
  • Philip John
Doctoral students
Known for CEO of BBSRC
Notable awards
Spouse Dr Antje Wagner (m. 1989)[1]
Children one son, two daughters[1]

Website

Douglas Bruce Kell CBE[20] FLSW (born 7 April 1953) is a British biochemist and Professor of Bioanalytical Sciences in the School of Chemistry at the University of Manchester, based in the Manchester Institute of Biotechnology (MIB).[21] He was formerly Chief Executive Officer (CEO) of the Biotechnology and Biological Sciences Research Council (BBSRC) from 2008-2013.[22][23][24][25][26][27][28][29]

Education

He was educated at Hydneye House in Sussex,[30] Bradfield College in Berkshire and St John's College, Oxford. He graduated with a Bachelor of Arts in Biochemistry in 1975 and a Doctor of Philosophy (Oxon) in 1978 with a thesis on the Bioenergetics of Paracoccus denitrificans supervised by Stuart John Ferguson[3][31] and Philip John.[32]

From 1978 to 2002 he worked at Aberystwyth University, moving to UMIST in 2002 as EPSRC/Royal Society of Chemistry Research Chair in Bioanalytical Sciences.

Research

According to Google Scholar[2] his most cited peer-reviewed research papers are in functional genomics,[33] metabolomics[34] and the yeast genome.[35] He has also been involved in research to create a Robot Scientist[36] in collaboration with Ross King, Stephen Muggleton and Steve Oliver as well as several projects in systems biology[37][38][39][40][41]

Kell's research has been funded by the BBSRC, the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council.[42][43]

Awards and honours

Kell was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science and research.[20]

Kell is also a Fellow of the Learned Society of Wales (FLSW), the Royal Society of Biology (FRSB) and the American Association for the Advancement of Science (FAAAS).

References

  1. 1 2 3 4 KELL, Prof. Douglas Bruce. Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. 1 2 Douglas Kell's publications indexed by Google Scholar
  3. 1 2 Kell, D.; John, P.; Ferguson, S. (1978). "The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans. Magnitude, sites of generation and comparison with the phosphorylation potential". The Biochemical Journal. 174 (1): 257–266. doi:10.1042/bj1740257. PMC 1185905Freely accessible. PMID 212022.
  4. ↑ Zelena, Eva (2009). Application of ultra performance liquid chromatography mass spectrometry to metabolic profiling of human serum and plasma (PhD thesis). University of Manchester.
  5. ↑ Zelena, E.; Dunn, W. B.; Broadhurst, D.; Francis-Mcintyre, S.; Carroll, K. M.; Begley, P.; O'Hagan, S.; Knowles, J. D.; Halsall, A.; Husermet, I. D.; Wilson, D. B.; Kell, D. B. (2009). "Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum". Analytical Chemistry. 81 (4): 1357–1364. doi:10.1021/ac8019366. PMID 19170513.
  6. ↑ Williamson, Thomas Charles (2009). Systems studies of the cAMP pathway and Glycolytic Oscillations in Saccharomyces cerevisiae (PhD thesis). University of Manchester.
  7. ↑ Williamson, T.; Schwartz, J. M.; Kell, D. B.; Stateva, L. (2009). "Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae". BMC Systems Biology. 3: 70. doi:10.1186/1752-0509-3-70. PMC 2719611Freely accessible. PMID 19607691.
  8. ↑ Ihekwaba, Adaoha Elizabeth (2005). Modelling of cellular signal transduction process using numerical simulation techniques (PhD thesis). University of Manchester.
  9. ↑ Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R. L.; Benson, N.; Kell, D. B. (2004). "Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: The roles of IKK and IkappaBalpha". Systems biology. 1 (1): 93–103. doi:10.1049/sb:20045009. PMID 17052119.
  10. ↑ Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R.; Benson, N.; White, M. R.; Kell, D. B. (2005). "Synergistic control of oscillations in the NF-kappaB signalling pathway". Systems biology. 152 (3): 153–160. doi:10.1049/ip-syb:20050050. PMID 16986278.
  11. ↑ Brown, Maria Cecilia (2006). Metabolic footprinting: computational analysis of post-genomic data (PhD thesis). University of Manchester.
  12. ↑ Brown, M.; Wedge, D. C.; Goodacre, R.; Kell, D. B.; Baker, P. N.; Kenny, L. C.; Mamas, M. A.; Neyses, L.; Dunn, W. B. (2011). "Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets". Bioinformatics. 27 (8): 1108–1112. doi:10.1093/bioinformatics/btr079. PMC 3709197Freely accessible. PMID 21325300.
  13. ↑ Brown, M.; Dunn, W. B.; Dobson, P.; Patel, Y.; Winder, C. L.; Francis-Mcintyre, S.; Begley, P.; Carroll, K.; Broadhurst, D.; Tseng, A.; Swainston, N.; Spasic, I.; Goodacre, R.; Kell, D. B. (2009). "Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics". The Analyst. 134 (7): 1322–1332. Bibcode:2009Ana...134.1322B. doi:10.1039/b901179j. PMID 19562197.
  14. ↑ Handl, Julia Karena (2006). Multiobjective approaches to the data-driven analysis of biological systems (PhD thesis). University of Manchester.
  15. ↑ Handl, J.; Kell, D. B.; Knowles, J. (2007). "Multiobjective Optimization in Bioinformatics and Computational Biology". IEEE/ACM Transactions on Computational Biology and Bioinformatics. 4 (2): 279–292. doi:10.1109/TCBB.2007.070203. PMID 17473320.
  16. ↑ Handl, J.; Knowles, J.; Kell, D. B. (2005). "Computational cluster validation in post-genomic data analysis". Bioinformatics. 21 (15): 3201–3212. doi:10.1093/bioinformatics/bti517. PMID 15914541.
  17. ↑ Mendes, Pedro Pedrosa (1994). Computer simulation of the dynamics of biochemical pathways (PhD thesis). University of Aberystwyth.
  18. ↑ "AAAS - 2012 Fellows". Archived from the original on 2012-02-18.
  19. ↑ "26 April 2012 - BBSRC Chief Executive elected as Fellow of the Learned Society of Wales - News - BBSRC". Archived from the original on 2012-04-27.
  20. 1 2 3 The London Gazette: (Supplement) no. 60728. p. 9. 31 December 2013.
  21. ↑ "Prof Douglas Kell, research profile - personal details (The University of Manchester)". Retrieved 2012-06-12.
  22. ↑ "19 June 2012 - Reappointment of Chief Executive for the Biotechnology and Biological Sciences Research Council - News - BBSRC". Archived from the original on 2012-06-26.
  23. ↑ http://www.rsc.org/chemistryworld/News/2008/November/24110801.asp Douglas Kell interview
  24. ↑ List of publications from Microsoft Academic Search
  25. ↑ Interview with Douglas Kell on the website of the Royal Society of Chemistry
  26. ↑ Douglas Kell from the ACM Digital Library
  27. ↑ Douglas Kell publications from Europe PubMed Central
  28. ↑ Douglas Kell on Twitter
  29. ↑ Kell, D. B.; Lurie-Luke, E (2015). "The virtue of innovation: Innovation through the lenses of biological evolution". Journal of the Royal Society Interface. 12 (103): 20141183. doi:10.1098/rsif.2014.1183. PMID 25505138.
  30. ↑ "Hydneye House - a set on Flickr". Archived from the original on 2013-04-25.
  31. ↑ "Prof Stuart Ferguson Page - Department of Biochemistry, University of Oxford". Archived from the original on 2013-04-25.
  32. ↑ Kell, Douglas Bruce (1978). The bioenergetics of paracoccus denitrificans (PhD thesis). University of Oxford.
  33. ↑ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology. 19 (1): 45–50. doi:10.1038/83496. PMID 11135551.
  34. ↑ Goodacre, R.; Vaidyanathan, S.; Dunn, W. B.; Harrigan, G. G.; Kell, D. B. (2004). "Metabolomics by numbers: Acquiring and understanding global metabolite data". Trends in Biotechnology. 22 (5): 245–252. doi:10.1016/j.tibtech.2004.03.007. PMID 15109811.
  35. ↑ Oliver, S.; Winson, M.; Kell, D.; Baganz, F. (1998). "Systematic functional analysis of the yeast genome". Trends in Biotechnology. 16 (9): 373–378. doi:10.1016/S0167-7799(98)01214-1. PMID 9744112.
  36. ↑ King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature. 427 (6971): 247–252. Bibcode:2004Natur.427..247K. doi:10.1038/nature02236. PMID 14724639.
  37. ↑ Kell, D. (2009). "Journal club: A systems biologist ponders how disparate ideas can sometimes come together beautifully". Nature. 460 (7256): 669–669. Bibcode:2009Natur.460..669K. doi:10.1038/460669e. PMID 19661875.
  38. ↑ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology. 4: 145. doi:10.1186/1752-0509-4-145. PMC 2988745Freely accessible. PMID 21029416.
  39. ↑ Pir, P.; Gutteridge, A.; Wu, J.; Rash, B.; Kell, D. B.; Zhang, N.; Oliver, S. G. (2012). "The genetic control of growth rate: A systems biology study in yeast". BMC Systems Biology. 6: 4. doi:10.1186/1752-0509-6-4. PMC 3398284Freely accessible. PMID 22244311.
  40. ↑ Douglas B. Kell at DBLP Bibliography Server
  41. ↑ Douglas Kell's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  42. ↑ UK Government Grants awarded to Douglas Kell, via Research Councils UK
  43. ↑ Grants awarded to Douglas Kell by the Engineering and Physical Sciences Research Council
Government offices
Preceded by
Julia Goodfellow		 CEO of the Biotechnology and Biological Sciences Research Council
2008–2013 		Succeeded by
Jackie Hunter
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