Genetic architecture

Genetic architecture refers to the underlying genetic basis of a phenotypic trait and its variational properties.[1] Phenotypic variation for quantitative traits is, at the most basic level, the result of the segregation of alleles at quantitative trait loci (QTL).[2] Environmental factors and other external influences can also play a role in phenotypic variation. Genetic architecture is a broad term that can be described for any given individual based on information regarding gene and allele number, the distribution of allelic and mutational effects, and patterns of pleiotropy, dominance, and epistasis.[1]

There are several different experimental views of genetic architecture. Some researchers recognize that the interplay of various genetic mechanisms is incredibly complex, but believe that these mechanisms can be averaged and treated, more or less, like statistical noise.[3] Other researchers claim that each and every gene interaction is significant and that it is necessary to measure and model these individual systemic influences on evolutionary genetics.[1]

Applications

Genotype-Phenotype Map
A very simple genotype-phenotype map that only shows additive pleiotropy effects.

Genetic architecture can be studied and applied at many different levels. At the most basic, individual level, genetic architecture describes the genetic basis for differences between individuals, species, and populations. This can include, among other details, how many genes are involved in a specific phenotype and how gene interactions, such as epistasis, influence that phenotype.[1] Line-cross analyses and QTL analyses can be used to study these differences.[2] This is perhaps the most common way that genetic architecture is studied, and though it is useful for supplying pieces of information, it does not generally provide a complete picture of the genetic architecture as a whole.

Genetic architecture can also be used to discuss the evolution of populations.[1] Classical quantitative genetics models, such as that developed by R.A. Fisher, are based on analyses of phenotype in terms of the contributions from different genes and their interactions.[3] Genetic architecture is sometimes studied using a genotype-phenotype map, which graphically depicts the relationship between the genotype and the phenotype.[4]

Genetic architecture is incredibly important for understanding evolutionary theory because it describes phenotypic variation in its underlying genetic terms, and thus it gives us clues about the evolutionary potential of these variations. Therefore, genetic architecture can help us to answer biological questions about speciation, the evolution of sex and recombination, the survival of small populations, inbreeding, understanding diseases, animal and plant breeding, and more.[1]

Evolvability

Evolvability is literally defined as the ability to evolve. In terms of genetics, evolvability is the ability of a genetic system to produce and maintain potentially adaptive genetic variants. There are several aspects of genetic architecture that contribute strongly to the evolvability of a system, including autonomy, mutability, coordination, epistasis, pleiotropy, polygeny, and robustness.[1][2]

Examples

Skin Color Model
A speculative framework for the evolutionary history underlying current-day phenotypic variation in human skin pigmentation based on the similarities and differences found in various genotypes.

A study published in 2006 used phylogeny to compare the genetic architecture of differing human skin color. In this study, researchers were able to suggest a speculative framework for the evolutionary history underlying current-day phenotypic variation in human skin pigmentation based on the similarities and differences they found in the genotype.[6] Evolutionary history is an important consideration in understanding the genetic basis of any trait, and this study was among the first to utilize these concepts in a paired fashion to determine information about the underlying genetics of a phenotypic trait.

In 2013, a group of researchers used genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS) to determine the risk of congenital heart defects in patients suffering from Down Syndrome.[7] Down Syndrome is a genetic disorder caused by trisomy of human chromosome 21. The current hypothesis regarding congenital heart defect phenotypes in Down Syndrome individuals is that three copies of functional genomic elements on chromosome 21 and genetic variation of chromosome 21 and non-chromosome 21 loci predispose patients to abnormal heart development. This study identified several congenital heart defect risk loci in Down Syndrome individuals, as well as three copy number variation (CNV) regions that may contribute to congenital heart defects in Down Syndrome individuals.

Another study, which was published in 2014, sought to identify the genetic architecture of psychiatric disorders. The researchers in this study suggested that there are a large number of contributing loci that are related to various psychiatric disorders.[8] Additionally, they, like many others, suggested that the genetic risk of psychiatric disorders involves the combined effects of many common variants with small effects - in other words, the small effects of a wide number of variants at specific loci add together to produce a large, combined effect on the overall phenotype of the individual. They also acknowledged the presence of large but rare mutations that have a large effect on phenotype. This study showcases the intricacy of genetic architecture by providing an example of many different SNPs and mutations working together, each with a varying effect, to generate a given phenotype.

Other studies regarding genetic architecture are many and varied, but most use similar types of analyses to provide specific information regarding loci involved in producing a phenotype. A study of the human immune system in 2015[9] uses the same general concepts to identify several loci involved in the development of the immune system, but, like the other studies outlined here, failed to consider other aspects of genetic architecture, such as environmental influences. Unfortunately, many other aspects of genetic architecture remain difficult to quantify.

Although there are a few studies that seek to explore the other aspects of genetic architecture, there is little ability with current technologies to link all of the pieces together to build a truly comprehensive model of genetic architecture. For example, in 2003, a study of genetic architecture and the environment was able to show an association of social environment with variation in body size in Drosophila melanogaster.[10] However, this study was not able to tie a direct link to specific genes involved in this variation.

External links

See also

References

  1. 1 2 3 4 5 6 7 Hansen, Thomas F. (2006-01-01). "The Evolution of Genetic Architecture". Annual Review of Ecology, Evolution, and Systematics. 37 (1): 123–157. doi:10.1146/annurev.ecolsys.37.091305.110224.
  2. 1 2 3 Mackay, Trudy F. C. (2001-01-01). "The Genetic Architecture of Quantitative Traits". Annual Review of Genetics. 35 (1): 303–339. doi:10.1146/annurev.genet.35.102401.090633. PMID 11700286.
  3. 1 2 Fisher, R. A. (1930-01-01). The Genetical Theory Of Natural Selection. At The Clarendon Press.
  4. ↑ Stadler, Peter F.; Stadler, Bärbel M. R. (2015-04-14). "Genotype-Phenotype Maps". Biological Theory. 1 (3): 268–279. doi:10.1162/biot.2006.1.3.268. ISSN 1555-5542.
  5. ↑ Lewontin, R. C. (1978-09-01). "Adaptation". Scientific American. 239 (3): 212–218, 220, 222 passim. doi:10.1038/scientificamerican0978-212. ISSN 0036-8733. PMID 705323.
  6. ↑ McEvoy, Brian; Beleza, Sandra; Shriver, Mark D. (2006-10-15). "The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model". Human Molecular Genetics. 15 (suppl 2): R176–R181. doi:10.1093/hmg/ddl217. ISSN 0964-6906. PMID 16987881.
  7. ↑ Sailani, M. Reza; Makrythanasis, Periklis; Valsesia, Armand; Santoni, Federico A.; Deutsch, Samuel; Popadin, Konstantin; Borel, Christelle; Migliavacca, Eugenia; Sharp, Andrew J. (2013-09-01). "The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome". Genome Research. 23 (9): 1410–1421. doi:10.1101/gr.147991.112. ISSN 1549-5469. PMC 3759718Freely accessible. PMID 23783273.
  8. ↑ Gratten, Jacob; Wray, Naomi R.; Keller, Matthew C.; Visscher, Peter M. (2014-06-01). "Large-scale genomics unveils the genetic architecture of psychiatric disorders". Nature Neuroscience. 17 (6): 782–790. doi:10.1038/nn.3708. ISSN 1546-1726. PMC 4112149Freely accessible. PMID 24866044.
  9. ↑ Roederer, Mario; Quaye, Lydia; Mangino, Massimo; Beddall, Margaret H.; Mahnke, Yolanda; Chattopadhyay, Pratip; Tosi, Isabella; Napolitano, Luca; Terranova Barberio, Manuela (2015-04-09). "The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis". Cell. 161 (2): 387–403. doi:10.1016/j.cell.2015.02.046. ISSN 0092-8674. PMC 4393780Freely accessible. PMID 25772697.
  10. ↑ Wolf, Jason B. (2003-04-15). "Genetic architecture and evolutionary constraint when the environment contains genes". Proceedings of the National Academy of Sciences. 100 (8): 4655–4660. doi:10.1073/pnas.0635741100. ISSN 0027-8424. PMC 153611Freely accessible. PMID 12640144.
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