Human mammary tumor virus

Human mammary tumor virus
Virus classification
Group: Group VI (ssRNA-RT)
Order: Unassigned
Family: Retroviridae
Subfamily: Orthoretrovirinae
Genus: Betaretrovirus
Species: Human mammary tumor virus

Human mammary tumor virus (HMTV) is a B-type retrovirus that is closely related to the mouse mammary tumor virus (MMTV).[1] The existence of this virus was suspected for decades[2] but nucleotide sequences identifying a unique virus in human breast cancer tumors were not confirmed until 2001.[3] Viral particles were isolated several years later.[4] Evidence for a role of HTMV/MMTV in human breast cancer has recently been reviewed.[5]

References

  1. ↑ Nartey, Teiko; Moran, Heberth; Marin, Tania; Arcaro, Kathleen F; Anderton, Douglas L; Etkind, Polly; Holland, James F; Melana, Stella M; Pogo, Beatriz G-T (2014). "Human Mammary Tumor Virus (HMTV) sequences in human milk". Infectious Agents and Cancer. 9 (1): 20. doi:10.1186/1750-9378-9-20.
  2. ↑ Moore, Dan H.; Sarkar, Nurul H.; Kramarsky, Bernhard; Lasfargues, E. Y.; Charney, Jesse (December 1971). "Some aspects of the search for a human mammary tumor virus". Cancer. 28 (6): 1415–1424. doi:10.1002/1097-0142(197112)28:6<1415::AID-CNCR2820280614>3.0.CO;2-Z.
  3. ↑ Liu, B; Wang, Y; Melana, SM; Pelisson, I; Najfeld, V; Holland, JF; Pogo, BG (15 February 2001). "Identification of a proviral structure in human breast cancer.". Cancer Research. 61 (4): 1754–9. PMID 11245493.
  4. ↑ Melana, SM; Nepomnaschy, I; Sakalian, M; Abbott, A; Hasa, J; Holland, JF; Pogo, BG (15 September 2007). "Characterization of viral particles isolated from primary cultures of human breast cancer cells.". Cancer Research. 67 (18): 8960–5. doi:10.1158/0008-5472.CAN-06-3892. PMID 17875739.
  5. ↑ Salmons, Brian; Lawson, James S.; Gunzburg, Walter H. (December 2014). "Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?.". Journal of General Virology. 95 (12): 2589–93. doi:10.1099/vir.0.070631-0. PMID 25217613.
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