Integrin-linked kinase

ILK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HI9, 2KBX, 3F6Q, 3IXE, 3KMU, 3KMW, 3REP, 4HI8
Identifiers
Aliases	ILK, HEL-S-28, ILK-1, ILK-2, P59, p59integrin linked kinase
External IDs	MGI: 1195267 HomoloGene: 3318 GeneCards: ILK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • SH3 domain binding • signal transducer activity • kinase activity • integrin binding • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding Cellular component • cytoplasm • cytosol • cell projection • membrane • cell-cell junction • focal adhesion • extracellular matrix • plasma membrane • sarcomere • stress fiber • nucleoplasm • protein complex • dendritic shaft • cell junction • neuronal cell body • terminal bouton • axon • costamere • lamellipodium Biological process • fibroblast migration • negative regulation of neuron apoptotic process • negative regulation of smooth muscle cell proliferation • neuron projection morphogenesis • positive regulation of protein kinase B signaling • regulation of actin cytoskeleton organization • positive regulation of MAP kinase activity • protein kinase B signaling • protein heterooligomerization • negative regulation of protein kinase activity • phosphorylation • myelin assembly • positive regulation of cell-matrix adhesion • positive regulation of cell migration • positive regulation of canonical Wnt signaling pathway • Schwann cell development • negative regulation of neural precursor cell proliferation • outflow tract morphogenesis • negative regulation of smooth muscle cell migration • negative regulation of apoptotic process • myelination in peripheral nervous system • positive regulation of axonogenesis • positive regulation of transcription, DNA-templated • cell aging • protein phosphorylation • negative regulation of cardiac muscle cell apoptotic process • branching involved in ureteric bud morphogenesis • positive regulation of osteoblast differentiation • positive regulation of dendrite morphogenesis • cell projection organization • positive regulation of myoblast differentiation • peptidyl-serine phosphorylation • cell cycle arrest • establishment or maintenance of epithelial cell apical/basal polarity • regulation of cell growth • positive regulation of cell proliferation • positive regulation of BMP signaling pathway • integrin-mediated signaling pathway • extracellular fibril organization • substrate adhesion-dependent cell spreading • positive regulation of phosphorylation • cell-matrix adhesion • cell proliferation • positive regulation of axon extension • platelet aggregation • nerve development • positive regulation of MAPK cascade • cell junction assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3611	16202
Ensembl	ENSG00000166333	ENSMUSG00000030890
UniProt	Q13418	O55222
RefSeq (mRNA)	NM_001014794 NM_001014795 NM_001278441 NM_001278442 NM_004517	NM_001161724 NM_010562
RefSeq (protein)	NP_001014794.1 NP_001014795.1 NP_001265370.1 NP_001265371.1 NP_004508.1	NP_001155196.1 NP_034692.2
Location (UCSC)	Chr 11: 6.6 – 6.61 Mb	Chr 7: 105.74 – 105.74 Mb
PubMed search	[1]	[2]
Wikidata

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, and signal transduction.

Function

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3] Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.^[4][5][6]

In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.^[7]

Interactions

Integrin-linked kinase has been shown to interact with:

References

Further reading