Isotuberculosinol synthase
| Isotuberculosinol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.7.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Isotuberculosinol synthase (EC 3.1.7.9, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming).[1][2] This enzyme catalyses the following chemical reaction
- tuberculosinyl diphosphate + H2O (13S)-isotuberculosinol + diphosphate
This enzyme is present in species of Mycobacterium that cause tuberculosis.
References
- ↑ Nakano, C.; Ootsuka, T.; Takayama, K.; Mitsui, T.; Sato, T.; Hoshino, T. (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Biosci. Biotechnol. Biochem. 75 (1): 75–81. doi:10.1271/bbb.100570. PMID 21228491.
- ↑ Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T. (2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Org. Biomol. Chem. 9 (7): 2156–2165. doi:10.1039/c0ob00884b. PMID 21290071.
External links
- Isotuberculosinol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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