mir-196 microRNA precursor family

mir-196 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-196
Identifiers
Symbol mir-196
Rfam RF00256
miRBase MI0000238
miRBase family MIPF0000031
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in human (MI0000238, MI0000279) and mouse (MI0000552, MI0000553).[1][2] miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000031). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation—their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin.

It has been suggested that a rare SNP (rs11614913) that overlaps has-mir-196a2 has been found to be associated with non-small cell lung carcinoma.[3]

Further reading

References

  1. ↑ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human.". RNA. 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382Freely accessible. PMID 12554859.
  2. ↑ Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003). "Vertebrate microRNA genes.". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257.
  3. ↑ Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008). "Genetic variants of miRNA sequences and non-small cell lung cancer survival". J Clin Invest. 118 (7): 2600–8. doi:10.1172/JCI34934. PMC 2402113Freely accessible. PMID 18521189.
  4. ↑ Zhang XW, Pan SD, Feng YL, Liu JB, Dong J, Zhang YX, Chen JG, Hu ZB, Shen HB (2011). "[Relationship between genetic polymorphism in microRNAs precursor and genetic prediposition of hepatocellular carcinoma].". Zhonghua Yu Fang Yi Xue Za Zhi. 45 (3): 239–43. PMID 21624236.
  5. ↑ Georges M (2011). "The long and winding road from correlation to causation.". Nat Genet. 43 (3): 180–1. doi:10.1038/ng0311-180. PMID 21350497.
  6. ↑ Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hébuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P (2011). "A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.". Nat Genet. 43 (3): 242–5. doi:10.1038/ng.762. PMID 21278745.
  7. ↑ Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q (2011). "MicroRNA-196: critical roles and clinical applications in development and cancer.". J Cell Mol Med. 15 (1): 14–23. doi:10.1111/j.1582-4934.2010.01219.x. PMC 3276076Freely accessible. PMID 21091634.
  8. ↑ Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E, Antonelli G (2010). "Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha.". Virol J. 7: 311. doi:10.1186/1743-422X-7-311. PMC 2996368Freely accessible. PMID 21070682.
  9. ↑ Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S (2010). "Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.". Cancer Res. 70 (20): 7894–904. doi:10.1158/0008-5472.CAN-10-1675. PMC 2955846Freely accessible. PMID 20736365.
  10. ↑ Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, Suzuki SO, Araki Y, Kuga D, Nakamizo A, Amano T, Ma X, Hayashi K, Sasaki T (2010). "MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance.". Clin Cancer Res. 16 (16): 4289–97. doi:10.1158/1078-0432.CCR-10-0207. PMID 20601442.
  11. ↑ Asli NS, Kessel M (2010). "Spatiotemporally restricted regulation of generic motor neuron programs by miR-196-mediated repression of Hoxb8.". Dev Biol. 344 (2): 857–68. doi:10.1016/j.ydbio.2010.06.003. PMID 20553899.
  12. ↑ Schotte D, Lange-Turenhout EA, Stumpel DJ, Stam RW, Buijs-Gladdines JG, Meijerink JP, Pieters R, Den Boer ML (2010). "Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia.". Haematologica. 95 (10): 1675–82. doi:10.3324/haematol.2010.023481. PMC 2948092Freely accessible. PMID 20494936.
  13. ↑ Hou W, Tian Q, Zheng J, Bonkovsky HL (2010). "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins.". Hepatology. 51 (5): 1494–504. doi:10.1002/hep.23401. PMC 2862129Freely accessible. PMID 20127796.
  14. ↑ McGlinn E, Yekta S, Mansfield JH, Soutschek J, Bartel DP, Tabin CJ (2009). "In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation.". Proc Natl Acad Sci U S A. 106 (44): 18610–5. doi:10.1073/pnas.0910374106. PMC 2773993Freely accessible. PMID 19846767.
  15. ↑ Sehm T, Sachse C, Frenzel C, Echeverri K (2009). "miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events.". Dev Biol. 334 (2): 468–80. doi:10.1016/j.ydbio.2009.08.008. PMID 19682983.
  16. ↑ Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ (2009). "Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.". Blood. 113 (14): 3314–22. doi:10.1182/blood-2008-04-154310. PMC 2665896Freely accessible. PMID 19188669.
  17. ↑ Sonkoly E, Ståhle M, Pivarcsi A (2008). "MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation.". Semin Cancer Biol. 18 (2): 131–40. doi:10.1016/j.semcancer.2008.01.005. PMID 18291670.
  18. ↑ Woltering JM, Durston AJ (2008). "MiR-10 represses HoxB1a and HoxB3a in zebrafish.". PLoS ONE. 3 (1): e1396. doi:10.1371/journal.pone.0001396. PMC 2148072Freely accessible. PMID 18167555.
  19. ↑ Richardson MK, Crooijmans RP, Groenen MA (2007). "Sequencing and genomic annotation of the chicken (Gallus gallus) Hox clusters, and mapping of evolutionarily conserved regions.". Cytogenet Genome Res. 117 (1-4): 110–9. doi:10.1159/000103171. PMID 17675851.
  20. ↑ Kawasaki H, Taira K (2004). "MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells.". Nucleic Acids Symp Ser (Oxf) (48): 211–2. doi:10.1093/nass/48.1.211. PMID 17150553.
  21. ↑ Chopra VS, Mishra RK (2006). ""Mir"acles in hox gene regulation.". BioEssays. 28 (5): 445–8. doi:10.1002/bies.20401. PMID 16615131.
  22. ↑ Ronshaugen M, Biemar F, Piel J, Levine M, Lai EC (2005). "The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings.". Genes Dev. 19 (24): 2947–52. doi:10.1101/gad.1372505. PMC 1315399Freely accessible. PMID 16357215.
  23. ↑ Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ (2005). "The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development.". Nature. 438 (7068): 671–4. doi:10.1038/nature04138. PMID 16319892.
  24. ↑ Yekta S, Shih IH, Bartel DP (2004). "MicroRNA-directed cleavage of HOXB8 mRNA.". Science. 304 (5670): 594–6. doi:10.1126/science.1097434. PMID 15105502.

External links

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