mir-24 microRNA precursor family
| mir-24 microRNA precursor family | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of mir-24 | |
| Identifiers | |
| Symbol | mir-24 |
| Rfam | RF00178 |
| miRBase | MI0000080 |
| miRBase family | MIPF0000041 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation [2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.[3]
Targets of miR-24
- Lal et al. suggested that miR-24 suppresses the tumor suppressor p16(INK4a).[1]
- Lal et al. reported that mi-24 inhibits cell proliferation by targeting E2F2, MYC via binding to "seedless" 3'UTR microRNA recognition elements.[2]
- Amelio I. et al. suggest that miR-24 regulates keratinocyte differentiation, controlling actin-cytoskeleton dynamics via PAK4, Tsk5 and ArhGAP19 repression.[3]
- Wang et al. have shown that miR-24 reduces the mRNA and protein levels of human ALK4 by targeting the 3'-untranslated region of mRNA.[4]
- Mishra et al. suggest that miR-24 targets the DHFR gene.[5]
References
- 1 2 Lal A, Kim HH, Abdelmohsen K, et al. (2008). Preiss T, ed. "p16(INK4a) translation suppressed by miR-24". PLoS ONE. 3 (3): e1864. doi:10.1371/journal.pone.0001864. PMC 2274865
. PMID 18365017. 
- 1 2 Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J (2009). Preiss T, ed. "miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.". Molecular Cell. 35 (5): 610–25. doi:10.1016/j.molcel.2009.08.020. PMC 2757794. PMID 19748357.
- 1 2 Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G (October 2012). "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration". The Journal of Cell Biology. 199 (2): 347–63. doi:10.1083/jcb.201203134. PMID 23071155.
- ↑ Wang Q, Huang Z, Xue H, et al. (January 2008). "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4". Blood. 111 (2): 588–95. doi:10.1182/blood-2007-05-092718. PMID 17906079.
- ↑ Mishra PJ, Humeniuk R, Mishra PJ, Longo-Sorbello GS, Banerjee D, Bertino JR (August 2007). "A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance". Proceedings of the National Academy of Sciences of the United States of America. 104 (33): 13513–8. doi:10.1073/pnas.0706217104. PMC 1948927. PMID 17686970.