NPR1

NPR1
Identifiers
Aliases	NPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDs	MGI: 97371 HomoloGene: 37367 GeneCards: NPR1
Gene ontology Molecular function • protein kinase activity • nucleotide binding • G-protein coupled peptide receptor activity • hormone binding • guanylate cyclase activity • GTP binding • peptide hormone binding • lyase activity • natriuretic peptide receptor activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • ATP binding • protein kinase binding Cellular component • integral component of membrane • membrane • plasma membrane • receptor complex • integral component of plasma membrane • guanylate cyclase complex, soluble Biological process • regulation of vasodilation • negative regulation of smooth muscle cell proliferation • regulation of cardiac conduction • intracellular signal transduction • regulation of blood vessel size • positive regulation of renal sodium excretion • positive regulation of urine volume • body fluid secretion • cyclic nucleotide biosynthetic process • positive regulation of cGMP biosynthetic process • receptor guanylyl cyclase signaling pathway • regulation of blood pressure • cGMP biosynthetic process • protein phosphorylation • cell surface receptor signaling pathway • regulation of vascular permeability • dopamine metabolic process • negative regulation of cell growth • negative regulation of angiogenesis • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4881	18160
Ensembl	ENSG00000169418	ENSMUSG00000027931
UniProt	P16066	P18293
RefSeq (mRNA)	NM_000906	NM_008727
RefSeq (protein)	NP_000897.3	NP_032753.5
Location (UCSC)	Chr 1: 153.68 – 153.69 Mb	Chr 3: 90.45 – 90.47 Mb
PubMed search	[1]	[2]
Wikidata

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[3]

It is localized in the kidney^[4] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[4]

See also

• Atrial natriuretic peptide receptor

References

Further reading

External links

• NPR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.