Related to receptor tyrosine kinase

RYK
Identifiers
Aliases	RYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase
External IDs	OMIM: 600524 MGI: 101766 HomoloGene: 68287 GeneCards: RYK
Gene ontology Molecular function • nucleotide binding • protein tyrosine kinase activity • transferase activity • transmembrane signaling receptor activity • transmembrane receptor protein tyrosine kinase activity • kinase activity • Wnt-activated receptor activity • ATP binding • protein binding • frizzled binding • Wnt-protein binding • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway • protein kinase activity Cellular component • cytoplasm • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane • nucleus Biological process • positive regulation of MAPK cascade • corpus callosum development • signal transduction • canonical Wnt signaling pathway • non-canonical Wnt signaling pathway • neurogenesis • commissural neuron axon guidance • neuron projection development • protein phosphorylation • synapse assembly • chemorepulsion of dopaminergic neuron axon • neuron differentiation • cell proliferation in midbrain • phosphorylation • axonogenesis • axon guidance • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • peptidyl-tyrosine phosphorylation • midbrain dopaminergic neuron differentiation • planar cell polarity pathway involved in axon guidance • Wnt signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6259	20187
Ensembl	ENSG00000163785	ENSMUSG00000032547
UniProt	P34925	Q01887
RefSeq (mRNA)	NM_001005861 NM_002958	NM_001042607 NM_013649 NM_001284258
RefSeq (protein)	NP_001005861.1 NP_002949.2	NP_001036072.1 NP_038677.3
Location (UCSC)	Chr 3: 134.07 – 134.25 Mb	Chr 9: 102.83 – 102.91 Mb
PubMed search	[1]	[2]
Wikidata

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.^[3]

History

The gene encoding mouse RYK was first identified in 1992.^[4] Subsequently cDNA encoding the RYK protein have been isolated from the following species.^[5]

• rat
• chicken
• Human
• Zebrafish
• Drosophila and
• C. elegans

Structure

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal domain, an extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.^[5]

Function

RYK is involved in regulation of axon growth during development of the nervous system.^[6]

References

1. ↑ "Human PubMed Reference:". 
2. ↑ "Mouse PubMed Reference:". 
3. ↑ "Entrez Gene: RYK RYK receptor-like tyrosine kinase". 
4. ↑ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. doi:10.1073/pnas.89.24.11818. PMC 50648. PMID 1334548.  CS1 maint: Multiple names: authors list (link)
5. 1 2 Halford, MM; Stacker, S.A. (2001). "Revelations of the RYK receptor". BioEssays. 23 (1): 34–45. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307. 
6. ↑ Edmund R Hollis, Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, Anna Tury, Shih-Hsiu Wang, Maysam Pessian, Euna Jo, Alex Kolodkin, Yimin Zou. Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nature Neuroscience 2016; doi: 10.1038/nn.4282

Further reading