Paul M. Sharp

For other people called Paul Sharp, see Paul Sharp.
Paul Sharp
Born Paul Martin Sharp
(1957-09-12) 12 September 1957[1]
Fields
Institutions
Alma mater University of Edinburgh (PhD)
Thesis Quantitative genetics of Drosophila melanogaster - variation in male mating ability (1982)
Doctoral students
Known for
Notable awards
Website
www.research.ed.ac.uk/portal/en/persons/paul-sharp(ed91461c-d4f2-497d-8621-2ec9be212726).html

Paul Martin Sharp (born 1957) FRS[14] FRSE[13] MRIA is Professor of Genetics at the University of Edinburgh, where he holds the Alan Robertson chair of genetics in the Institute of Evolutionary Biology.[15][16][17]

Education

Sharp was educated at the University of Edinburgh where he was awarded a Bachelor of Science degree in 1979[12] followed by a PhD in 1982 for research using quantitative genetics on the fruit fly Drosophila melanogaster.[15][18]

Career and research

Sharp has held academic posts at Trinity College, Dublin from 1982 to 1993,[4] the University of Nottingham from 1993 to 2007[4] and was appointed Professor at the University of Edinburgh in 2007.[4]

Sharp's research investigates the evolutionary origin of bacteria and viruses.[14][19][20] He has carried out important work into the origin of HIV and its transmission from chimpanzees to humans. He also discovered that the human malaria parasite, Plasmodium, originated in gorillas.[14] He was one of the first researchers to use DNA sequence databases to gain insight into evolutionary processes. His work amplifying DNA from chimpanzee faecal samples showed that HIV type 1 was transmitted to humans from a specific chimp population in West Africa in the early 20th century. Paul went on to examine his collection of ape faecal samples for plasmodium parasites, finding a likely candidate for the form that causes malaria in humans.[14][21]

In the eighties, Sharp collaborated with Desmond G. Higgins during the creation of CLUSTAL,[9][10] a suite of multiple sequence alignment programs that have become widely used and highly influential.[22] His research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC).[23]

Awards and honours

Sharp was elected member of the European Molecular Biology Organization (EMBO) in 1992,[11] and was President of the Society for Molecular Biology and Evolution. He was elected member of the Royal Irish Academy in 1993,[12] a Fellow of the Royal Society of Edinburgh (FRSE) in 2010[13] and a Fellow of the Royal Society (FRS) in 2013.[14]

References

  1. ↑ "Fellowship of the Royal Society 1660-2015". London: Royal Society. Archived from the original on 2015-07-15.
  2. 1 2 Sharp, Paul M.; Li, Wen-Hsiung (1987). "The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications". Nucleic Acids Research. 15 (3): 1281–1295. doi:10.1093/nar/15.3.1281. PMC 340524Freely accessible. PMID 3547335.
  3. ↑ Paul M. Sharp's publications indexed by Google Scholar
  4. 1 2 3 4 Paul Sharp's Entry at ORCID
  5. ↑ Emery, Laura R. (2011). Codon usage bias in Archaea (PhD thesis). University of Edinburgh. OCLC 827265443.
  6. ↑ McIntyre, Chloe Leanne (2013). Epidemiology, classification and evolution of human rhinoviruses (PhD thesis). University of Edinburgh. OCLC 870423031.
  7. ↑ Paul M. Sharp at the Mathematics Genealogy Project
  8. ↑ Wolfe, Kenneth H. (1990). Rates of nucleotide substitution in higher plants and mammals (PhD thesis). Trinity College, Dublin. OCLC 842511087.
  9. 1 2 Higgins, Desmond G.; Sharp, Paul M. (1988). "CLUSTAL: a package for performing multiple sequence alignment on a microcomputer". Gene. 73 (1): 237–244. doi:10.1016/0378-1119(88)90330-7.
  10. 1 2 Higgins, Desmond G.; Sharp, Paul M. (1989). "Fast and sensitive multiple sequence alignments on a microcomputer". Bioinformatics. 5 (2): 151–153. doi:10.1093/bioinformatics/5.2.151.
  11. 1 2 "Paul M. Sharp University of Edinburgh, United Kingdom". Hedelberg: EMBO. Archived from the original on 2016-01-19.
  12. 1 2 3 "Paul Martin Sharp BSc, PhD (Edin 1979, 1982). FRS, FRSE". Dublin: Royal Irish Academy. Archived from the original on 2016-04-13.
  13. 1 2 3 "Royal Society of Edinburgh Fellows as of 2016-05-13" (PDF). Edinburgh: Royal Society of Edinburgh. Archived from the original (PDF) on 2016-03-30.
  14. 1 2 3 4 5 6 "Professor Paul Sharp FRS". London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  15. 1 2 "Professor Paul M. Sharp, FRS, FRSE, MRIA: Alan Robertson Chair of Genetics". Edinburgh: University of Edinburgh. Archived from the original on 2016-04-12.
  16. ↑ Sharp, P. M.; Hahn, B. H. (2011). "Origins of HIV and the AIDS Pandemic". Cold Spring Harbor Perspectives in Medicine. 1 (1): a006841. doi:10.1101/cshperspect.a006841. PMC 3234451Freely accessible. PMID 22229120.
  17. ↑ "Staff profiles: Institute of Evolutionary Biology". Edinburgh: University of Edinburgh. Archived from the original on 2015-09-17.
  18. ↑ Sharp, Paul Martin (1982). Quantitative genetics of Drosophila melanogaster : variation in male mating ability (PhD thesis). University of Edinburgh. OCLC 606022632.
  19. ↑ Paul M. Sharp's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  20. ↑ Hahn, Beatrice H.; Shaw, George M.; Cock, Kevin M. De; Sharp, Paul M. (2000). "AIDS as a Zoonosis: Scientific and Public Health Implications". Science. 287 (5453): 607–614. doi:10.1126/science.287.5453.607. PMID 10649986.
  21. ↑ Gao, Feng; Bailes, Elizabeth; Robertson, David L.; Chen, Yalu; Rodenburg, Cynthia M.; Michael, Scott F.; Cummins, Larry B.; Arthur, Larry O.; Peeters, Martine; Shaw, George M.; Sharp, Paul M.; Hahn, Beatrice H. (1999). "Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes". Nature. 397 (6718): 436–441. doi:10.1038/17130. PMID 9989410.
  22. ↑ Van Noorden, R.; Maher, B.; Nuzzo, R. (2014). "The top 100 papers: Nature explores the most-cited research of all time". Nature. London. 514 (7524): 550–3. doi:10.1038/514550a. PMID 25355343.
  23. ↑ "UK Government grants awarded to Paul M. Sharp". Swindon: Research Councils UK. Archived from the original on 2016-04-12.


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