Stephen R. Bloom

For other people called Stephen Bloom, see Stephen Bloom.
Sir Stephen Bloom
Born Stephen Robert Bloom
(1942-10-24) 24 October 1942[1]
Institutions
Alma mater University of Cambridge (MA, MD)
Doctoral students
Notable awards
Spouse Margaret Janet Bloom (née Sturrock) (m. 1965)[19][19]
Children four[1]

Sir Stephen Robert Bloom FRS[18] is a Professor of Medicine at Imperial College London where he leads the Diabetes, Endocrinology and Metabolism division.[20][21][22][23][24]

Education

Bloom was educated at Queens' College, Cambridge where he was awarded a Master of Arts degree in 1968 and a Doctor of Medicine degree in 1979.[1] He received his Doctor of Science (DSc) degree from the University of London in 1982. Bloom completed appointments as a house officer, senior house officer and specialist registrar at Middlesex Hospital, University College London, where he also received his Medical Research Council (MRC) Clinical Research Fellowship training.

Awards and honours

Bloom was elected a Fellow of the Royal Society (FRS) in 2013. His nomination reads:

“ Bloom played a seminal role in establishing the biology and pathophysiology of the intrinsic endocrine system of the gastrointestinal tract, an area which he pioneered and which is now a major focus of basic and applied laboratories worldwide. Through the identification of clinical syndromes associated with overproduction of these hormones and experimental physiological studies in man, Bloom established the physiological effects of these hormones. Importantly, he recognised that several gut derived peptides powerfully influenced glucose homeostasis and/or appetite, insights which have led to major developments in the treatment of Type 2 diabetes and obesity.[18] ”

Blooms research has been funded by grants awarded by the BBSRC and Medical Research Council (MRC).[25]

Bloom was also knighted in the Queen's 2012 New Year Honours, and awarded Fellowships of the Royal College of Physicians (FRCP), Royal College of Pathologists (FRCPath), the Academy of Medical Sciences (FMedSci) and the Royal Society of Biology (FRSB).

References

  1. 1 2 3 BLOOM, Prof. Sir Stephen (Robert). Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. ↑ Addison, Melisande L. (2011). Investigating PYY3-36 and PYY3-36 analogues in the development of an obesity therapy (PhD thesis). Imperial College London.
  3. ↑ Addison, M. L.; Minnion, J. S.; Shillito, J. C.; Suzuki, K; Tan, T. M.; Field, B. C.; Germain-Zito, N; Becker-Pauly, C; Ghatei, M. A.; Bloom, S. R.; Murphy, K. G. (2011). "A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36". Endocrinology. 152 (12): 4630–40. doi:10.1210/en.2011-1195. PMID 21952244.
  4. ↑ Buter, Marco (2011). Changes in food preference and taste responses after Roux-en-Y gastric bypass (PhD thesis). Imperial College London.
  5. ↑ Baxter, Jordan Eleanor (2011). The development of pancreatic polypeptide analogues as a pharmacotherapy for obesity (PhD thesis). Imperial College London.
  6. ↑ Nijher, Gurjinder Monica Kaur (2012). Investigation of the novel hormone kisspeptin in disorders of reproduction (PhD thesis). Imperial College London.
  7. ↑ Hussain, Syed Sufyan (2013). Investigating the physiological role of hypothalamic glucokinase in appetite and glucose homeostasis (PhD thesis). Imperial College London.
  8. ↑ Hussain, S; Richardson, E; Ma, Y; Holton, C; De Backer, I; Buckley, N; Dhillo, W; Bewick, G; Zhang, S; Carling, D; Bloom, S; Gardiner, J (2015). "Glucokinase activity in the arcuate nucleus regulates glucose intake". Journal of Clinical Investigation. 125 (1): 337–49. doi:10.1172/JCI77172. PMC 4382228Freely accessible. PMID 25485685.
  9. ↑ Parker, Jennifer (2013). The preproglucagon derived peptides and energy homeostasis (PhD thesis). Imperial College London.
  10. ↑ Parker, J. A.; Bloom, S. R. (2012). "Hypothalamic neuropeptides and the regulation of appetite". Neuropharmacology. 63 (1): 18–30. doi:10.1016/j.neuropharm.2012.02.004. PMID 22369786.
  11. ↑ Pournaras, Dimitrios (2012). Mechanisms maintaining reduced appetite and normoglycaemia after metabolic surgery : the role of bile acids (PhD thesis). Imperial College London.
  12. ↑ Pournaras, D. J.; Glicksman, C; Vincent, R. P.; Kuganolipava, S; Alaghband-Zadeh, J; Mahon, D; Bekker, J. H.; Ghatei, M. A.; Bloom, S. R.; Walters, J. R.; Welbourn, R; Le Roux, C. W. (2012). "The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control". Endocrinology. 153 (8): 3613–9. doi:10.1210/en.2011-2145. PMC 3404349Freely accessible. PMID 22673227.
  13. ↑ Salem, Victoria (2012). Anorectic gut hormones PYY and GLP-1 on brain appetite pathways : a human fMRI study (PhD thesis). Imperial College London.
  14. ↑ Tadross, John Alphonse (2011). The role of augurin in the hypothalamo-pituitary-adrenal axis and the regulation of food intake (PhD thesis). Imperial College London. OCLC 776769462.
  15. ↑ Tadross, J. A.; Patterson, M; Suzuki, K; Beale, K. E.; Boughton, C. K.; Smith, K. L.; Moore, S; Ghatei, M. A.; Bloom, S. R. (2010). "Augurin stimulates the hypothalamo-pituitary-adrenal axis via the release of corticotrophin-releasing factor in rats". British Journal of Pharmacology. 159 (8): 1663–71. doi:10.1111/j.1476-5381.2010.00655.x. PMC 2925489Freely accessible. PMID 20233222.
  16. ↑ Zac-Varghese, Sagen Elizabeth Kanissaril (2011). Investigation of gut hormone physiology in the regulation of appetite (PhD thesis). Imperial College London.
  17. ↑ Zac-Varghese, S; Trapp, S; Richards, P; Sayers, S; Sun, G; Bloom, S. R.; Reimann, F; Gribble, F. M.; Rutter, G. A. (2014). "The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice". Disease Models & Mechanisms. 7 (11): 1275–86. doi:10.1242/dmm.014720. PMC 4213731Freely accessible. PMID 25190708.
  18. 1 2 3 "Professor Stephen Bloom FRS". London: The Royal Society. Archived from the original on 2015-05-02.
  19. 1 2 BLOOM, Margaret Janet, (Lady Bloom). Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  20. ↑ Stephen R. Bloom's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  21. ↑ Batterham, R. L.; Cowley, M. A.; Small, C. J.; Herzog, H.; Cohen, M. A.; Dakin, C. L.; Wren, A. M.; Brynes, A. E.; Low, M. J.; Ghatei, M. A.; Cone, R. D.; Bloom, S. R. (2002). "Gut hormone PYY3-36 physiologically inhibits food intake". Nature. 418 (6898): 650–4. doi:10.1038/nature00887. PMID 12167864.
  22. ↑ Lechler, R. I.; Lord, G. M.; Matarese, G.; Howard, J. K.; Baker, R. J.; Bloom, S. R. (1998). "Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression". Nature. 394 (6696): 897–901. doi:10.1038/29795. PMID 9732873.
  23. ↑ Batterham, R. L.; Cohen, M. A.; Ellis, S. M.; Le Roux, C. W.; Withers, D. J.; Frost, G. S.; Ghatei, M. A.; Bloom, S. R. (2003). "Inhibition of food intake in obese subjects by peptide YY3-36". New England Journal of Medicine. 349 (10): 941–8. doi:10.1056/NEJMoa030204. PMID 12954742.
  24. ↑ "Professor Sir Stephen Bloom, FRS". Imperial College London. Archived from the original on 2014-11-18.
  25. ↑ "UK Government Grants awarded to Stephen R. Bloom". Research Councils UK. Archived from the original on 2015-06-08.
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