ProP (transporter)

Proline/betaine transporter
Identifiers
Organism Escherichia coli
Symbol ProP
PDB 1R48
UniProt P0C0L7

ProP is a bacterial membrane protein that is a member of the major facilitator superfamily. It functions as an osmosensory and osmoregulatory transporter, responding to changes in osmotic pressure by importing compatible solutes such as proline or glycine betaine;[1] most substrates for ProP are zwitterions.[2] The activity of ProP increases with osmotic pressure in cells and proteoliposomes.[3][4] ProP is a symporter of hydrogen ions and compatible solutes, and is responsive to potassium concentrations.[2]

Activity of ProP has been associated with the ability of pathogenic E. coli to colonize the urinary tract.[3]

References

  1. ↑ Culham, DE; Lasby, B; Marangoni, AG; Milner, JL; Steer, BA; van Nues, RW; Wood, JM (5 January 1993). "Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP.". Journal of molecular biology. 229 (1): 268–76. doi:10.1006/jmbi.1993.1030. PMID 8421314.
  2. 1 2 MacMillan, SV; Alexander, DA; Culham, DE; Kunte, HJ; Marshall, EV; Rochon, D; Wood, JM (20 August 1999). "The ion coupling and organic substrate specificities of osmoregulatory transporter ProP in Escherichia coli.". Biochimica et biophysica acta. 1420 (1-2): 30–44. doi:10.1016/s0005-2736(99)00085-1. PMID 10446288.
  3. 1 2 Culham, DE; Dalgado, C; Gyles, CL; Mamelak, D; MacLellan, S; Wood, JM (Jan 1998). "Osmoregulatory transporter ProP influences colonization of the urinary tract by Escherichia coli.". Microbiology (Reading, England). 144 ( Pt 1): 91–102. PMID 9467901.
  4. ↑ Racher, KI; Voegele, RT; Marshall, EV; Culham, DE; Wood, JM; Jung, H; Bacon, M; Cairns, MT; Ferguson, SM; Liang, WJ; Henderson, PJ; White, G; Hallett, FR (9 February 1999). "Purification and reconstitution of an osmosensor: transporter ProP of Escherichia coli senses and responds to osmotic shifts.". Biochemistry. 38 (6): 1676–84. doi:10.1021/bi981279n. PMID 10026245.
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