DNA topoisomerase

DNA topoisomerase
Identifiers
EC number 5.99.1.2
CAS number 80449-01-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase, omega-protein, deoxyribonucleate topoisomerase) is an enzyme with systematic name DNA topoisomerase.[1] This enzyme catalyses the following chemical reaction

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining

These enzymes bring about the conversion of one topological isomer of DNA into another.

References

  1. ↑ Gellert, M. (1981). "DNA topoisomerases". Annu. Rev. Biochem. 50: 879–910. doi:10.1146/annurev.bi.50.070181.004311. PMID 6267993.

See also

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