UBE2D1

UBE2D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C4P, 2YHO, 3OJ4, 3PTF, 4AP4, 4QPL, 5FER
Identifiers
Aliases	UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ubiquitin conjugating enzyme E2 D1
External IDs	MGI: 2384911 HomoloGene: 20714 GeneCards: UBE2D1
EC number	2.3.2.24
Gene ontology Molecular function • nucleotide binding • transferase activity • ubiquitin conjugating enzyme activity • ATP binding • protein binding • ubiquitin-protein transferase activity Cellular component • cytoplasm • nucleoplasm • cytosol • protein complex • ubiquitin ligase complex Biological process • protein K48-linked ubiquitination • BMP signaling pathway • protein polyubiquitination • Fc-epsilon receptor signaling pathway • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • TRIF-dependent toll-like receptor signaling pathway • stimulatory C-type lectin receptor signaling pathway • protein ubiquitination • anaphase-promoting complex-dependent catabolic process • positive regulation of protein ubiquitination • regulation of transcription from RNA polymerase II promoter in response to hypoxia • T cell receptor signaling pathway • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • ubiquitin-dependent protein catabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7321	216080
Ensembl	ENSG00000072401	ENSMUSG00000019927
UniProt	P51668	P61080
RefSeq (mRNA)	NM_003338 NM_001204880	NM_145420
RefSeq (protein)	NP_003329.1	NP_663395.1
Location (UCSC)	Chr 10: 58.33 – 58.37 Mb	Chr 10: 71.25 – 71.29 Mb
PubMed search	[1]	[2]
Wikidata

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.^[3][4][5]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.^[5]

Interactions

UBE2D1 has been shown to interact with:

• BARD1,^{[6][7][8][9][10][11][12][13]}
• BRCA1,^{[6][7][8][9][10][11][12][13][14][15]} and
• UBE3A.^[16][17]

References

Further reading

PDB gallery
2c4p: CRYSTAL STRUCTURE OF HUMAN UBIQUITIN-CONJUGATING ENZYME UBCH5A