ZFY

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1KLR, 1KLS, 1XRZ, 5ZNF

Identifiers

Aliases

ZFY, ZNF911, zinc finger protein, Y-linked

External IDs

HomoloGene: 88465 GeneCards: ZFY

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • metal ion binding • nucleic acid binding
Cellular component	• nucleus
Biological process	• multicellular organism development • regulation of transcription, DNA-templated • transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7544


n/a

Ensembl


ENSG00000067646


n/a

UniProt


P08048


n/a

RefSeq (mRNA)


NM_001145275 NM_001145276 NM_003411


n/a

RefSeq (protein)


NP_001138747.1 NP_001138748.1 NP_003402.2


n/a

Location (UCSC)

Chr Y: 2.94 – 2.98 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene.^[2]^[3]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.^[3]

References

↑ "Human PubMed Reference:".
↑ Muller G, Schempp W (Jun 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
1 2 "Entrez Gene: ZFY zinc finger protein, Y-linked".

Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells". Arch. Med. Res. 32 (6): 553–8. doi:10.1016/S0188-4409(01)00317-4. PMID 11750730.
Kochoyan M, Havel TF, Nguyen DT, et al. (1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition". Biochemistry. 30 (14): 3371–86. doi:10.1021/bi00228a004. PMID 1849423.
Kochoyan M, Keutmann HT, Weiss MA (1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition". Biochemistry. 30 (29): 7063–72. doi:10.1021/bi00243a005. PMID 1854720.
North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734.
Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929.
Affara NA, Chambers D, O'Brien J, et al. (1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9". Nucleic Acids Res. 17 (8): 2987–99. doi:10.1093/nar/17.8.2987. PMC 317707. PMID 2498838.
Lau YF, Chan KM (1990). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues". Am. J. Hum. Genet. 45 (6): 942–52. PMC 1683462. PMID 2511751.
Page DC, Mosher R, Simpson EM, et al. (1988). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091–104. doi:10.1016/0092-8674(87)90595-2. PMID 3690661.
Tricoli JV, Bracken RB (1993). "ZFY gene expression and retention in human prostate adenocarcinoma". Genes Chromosomes Cancer. 6 (2): 65–72. doi:10.1002/gcc.2870060202. PMID 7680890.
Erlandsson R, Wilson JF, Pääbo S (2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans". Mol. Biol. Evol. 17 (5): 804–12. doi:10.1093/oxfordjournals.molbev.a026359. PMID 10779541.
Mittwoch U (2001). "Three thousand years of questioning sex determination". Cytogenet. Cell Genet. 91 (1–4): 186–91. doi:10.1159/000056842. PMID 11173854.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1klr: NMR Structure of the ZFY-6T[Y10F] Zinc Finger

5znf: ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR ""JUMPING-LINKER"" DNA RECOGNITION

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ZFY

References

Further reading