AQP5
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Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.[3][4]
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[4]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
- 1 2 "Entrez Gene: AQP5 aquaporin 5".
Further reading
- Verkman AS (2003). "Role of aquaporin water channels in eye function.". Exp. Eye Res. 76 (2): 137–43. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
- Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13.". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
- Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands.". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.
- Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung.". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621.
- Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278.
- Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMC 117591
. PMID 11773623. - Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.". Gut. 52 (7): 1008–16. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells.". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
- Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions.". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
- Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress.". Pflugers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812.
- Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.
External links
- AQP5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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