Estradiol stearate
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| Clinical data | |
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| Trade names | Depofollan |
| Identifiers | |
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| CAS Number | 82205-00-3 |
| PubChem (CID) | 67100 |
| ChemSpider | 60448 |
| Chemical and physical data | |
| Formula | C36H58O3 |
| Molar mass | 538.857 g/mol |
| 3D model (Jmol) | Interactive image |
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Estradiol stearate (brand name Depofollan), or estradiol octadecanoate, is a naturally occurring[1] steroidal estrogen and an estrogen ester – specifically, the C17β stearate ester of estradiol.[2][3] It occurs in the body as a very long-lasting metabolite and prohormone of estradiol.[1] In addition, estradiol stearate is or has been available as a pharmaceutical drug for use via depot intramuscular injection.[2][3] The drug was introduced in 1941 as Depofollan and was the first long-acting estrogen, although it has never been widely used.[4] It has been reported in at least one source to have a duration of at least one month.[4]
See also
References
- 1 2 Hochberg RB, Pahuja SL, Larner JM, Zielinski JE (1990). "Estradiol-fatty acid esters. Endogenous long-lived estrogens". Ann. N. Y. Acad. Sci. 595: 74–92. PMID 2197972.
- 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3.
- 1 2 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 405–. ISBN 978-3-88763-075-1.
- 1 2 Orvostudomány. Magyar Tudomanyos Akadémia V. Orvosi Tudományok Osztálya. 1960. p. 11.
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