Methylpiperidinopyrazole
Identifiers | |
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CAS Number | 289726-02-9 |
PubChem (CID) | 6604927 |
ChemSpider | 5037183 |
Chemical and physical data | |
Formula | C29H31N3O3 |
Molar mass | 469.57474 g/mol |
3D model (Jmol) | Interactive image |
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Methylpiperidinopyrazole (MPP) is a synthetic, non-steroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor.[1][2][3] It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.[4]
See also
- Propylpyrazoletriol (PPT)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- PHTPP
- (R,R)-Tetrahydrochrysene ((R,R)-THC)
References
- ↑ Tony M. Plant; Anthony J. Zeleznik (15 November 2014). Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. pp. 2311–. ISBN 978-0-12-397769-4.
- ↑ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
- ↑ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS). ProQuest. 2008. pp. 11–. ISBN 978-0-549-90990-3.
- ↑ Eckhard Ottow; Hilmar Weinmann (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 50–. ISBN 978-3-527-62330-3.
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