HEYL

HEYL
Identifiers
Aliases	HEYL, HESR3, HEY3, HRT3, bHLHb33, hes related family bHLH transcription factor with YRPW motif-like
External IDs	MGI: 1860511 HomoloGene: 8494 GeneCards: HEYL
Gene ontology Molecular function • microsatellite binding • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription corepressor activity • transcription factor activity, protein binding • protein dimerization activity • protein homodimerization activity • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • protein binding • protein heterodimerization activity • AF-1 domain binding • RNA polymerase II core promoter sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter sequence-specific Cellular component • nucleoplasm • nucleus • cytoplasm Biological process • regulation of transcription, DNA-templated • negative regulation of androgen receptor signaling pathway • cellular response to BMP stimulus • glomerulus development • transcription from RNA polymerase II promoter • negative regulation of gene expression • transcription, DNA-templated • multicellular organism development • proximal tubule development • negative regulation of androgen receptor activity • skeletal muscle cell differentiation • Notch signaling pathway • negative regulation of transcription from RNA polymerase II promoter • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • outflow tract morphogenesis • atrioventricular valve morphogenesis • cardiac ventricle morphogenesis • cardiac epithelial to mesenchymal transition • mesenchymal cell development • pulmonary valve morphogenesis • epithelial to mesenchymal transition involved in endocardial cushion formation • ventricular septum morphogenesis • endocardial cushion morphogenesis • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26508	56198
Ensembl	ENSG00000163909	ENSMUSG00000032744
UniProt	Q9NQ87	Q9DBX7
RefSeq (mRNA)	NM_014571	NM_013905
RefSeq (protein)	NP_055386.1	NP_038933.2
Location (UCSC)	Chr 1: 39.62 – 39.64 Mb	Chr 4: 123.23 – 123.25 Mb
PubMed search	[1]	[2]
Wikidata

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.^[3][4][5]

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.^[5]

References

Further reading

External links

• HEYL protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.