Liver receptor homolog-1

NR5A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RWV, 1YOK, 1YUC, 1ZDU, 2A66, 3PLZ, 3TX7, 4DOR, 4DOS, 4IS8, 4ONI, 4PLD, 4PLE
Identifiers
Aliases	NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2, nuclear receptor subfamily 5 group A member 2
External IDs	OMIM: 604453 MGI: 1346834 HomoloGene: 20827 GeneCards: NR5A2
Genetically Related Diseases
pancreatic cancer[1]
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • double-stranded DNA binding • phospholipid binding • lipid binding Cellular component • cytoplasm • nucleoplasm • RNA polymerase II transcription factor complex • nucleus Biological process • regulation of transcription, DNA-templated • epithelial cell differentiation • pancreas morphogenesis • embryo development • bile acid metabolic process • transcription, DNA-templated • positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • regulation of cell proliferation • tissue development • hormone-mediated signaling pathway • cholesterol homeostasis • positive regulation of viral genome replication • transcription initiation from RNA polymerase II promoter • steroid hormone mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter • homeostatic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2494	26424
Ensembl	ENSG00000116833	ENSMUSG00000026398
UniProt	O00482	P45448
RefSeq (mRNA)	NM_001276464 NM_003822 NM_205860	NM_001159769 NM_030676
RefSeq (protein)	NP_001263393.1 NP_003813.1 NP_995582.1	NP_109601.1
Location (UCSC)	Chr 1: 200.03 – 200.18 Mb	Chr 1: 136.84 – 136.96 Mb
PubMed search	[2]	[3]
Wikidata

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.^[4][5] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.^[6][7][8]

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.^[9]

Interactions

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.^[10][11]

References

Further reading

External links

• NR5A2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery
1yok: crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol  1yuc: Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP  1zdu: The Crystal Structure of Human Liver Receptor Homologue-1  2a66: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter  2ff0: Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter