Monobactam

Aztreonam. (The four-membered ring at the bottom is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)

Tigemonam

Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring, in contrast to most other β-lactams. They are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas).

Currently the only commercially available monobactam antibiotic is aztreonam.

Other examples of monobactams are tigemonam,^[1] nocardicin A, and tabtoxin.

Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.

They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.

References

External links

• Monobactams at the US National Library of Medicine Medical Subject Headings (MeSH)